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ばらつきのない細胞増殖をサポート


動物ベースのサプリメント(動物細胞)を用いて作製されるタンパク質は天然のタンパク質と酷似しているため、最終の機能性に優れ、有害な免疫応答の可能性も抑制できます。また、動物細胞では、例えばグリコシル化などを通じて、作製するタンパク質の翻訳後修飾も可能です。

ただし、バイオプロセシングの観点から考えた場合、動物細胞はその利用に深刻な難しさがあります。動物培養は、多くの場合、従来の発酵プロセスよりも小さい規模で生産されますが、生産に付随する操作とスケールアップのパラメータ(サプリメントに関する要求条件、供給条件のコントロール、高度な培地の必要性)がはるかに複雑になります。つまり、自信を持って作業するためには、メルクのような経験の深いパートナーとの提携に決して損はありません。

Probumin®

With over five decades of protein fractionation expertise, Merck is the world’s largest and most experienced manufacturer for multiple grades of high quality albumins for the diagnostic and cell culture market.

Tailored to your needs
From albumins for nutrient-rich cell culture to highly purified albumins for diagnostic applications, every one of our Probumin® BSA grades is designed to meet a specific need. Whatever you require, you can take advantage of top quality, performance and safety –thanks to our fractionation technology, ISO certified facilities, US-sourced materials and proactive regulatory procedures.

Albumin is one of the most widely used proteins in the medical industry. Due to its availability, inherent stability and ligand binding ability, albumin is an essential component in the production of many therapeutic drugs and diagnostic tests.

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EX-CYTE® growth enhancement media supplement

Merck’s EX-CYTE® supplement can significantly improve your cell culture manufacturing process when used in conjunction with our other critical media supplements. It supplies critical growth factors without the need for full-serum supplementation, making it an ideal enhancer for reduced-serum cell culture.

Proven performance
EX-CYTE® supplement is a water-soluble concentrate of cholesterol, lipoproteins and fatty acids. It provides a balanced profile of metabolic factors that are proven to enhance cell growth and protein production in a variety of mammalian cells. These include hybridomas, myelomas, CHO and HEK293 cells.

Proven quality
Merck manufactures EX-CYTE® supplement in large batch sizes in compliance with cGMP guidelines, and test it rigorously for consistency, microbial content, clearance of bovine viruses (9 CFR 113), mycoplasma and endotoxins. It is heat pasteurized, and contains no organic solvents or detergents. EX-CYTE® supplement is made from US-sourced materials, while EX-CYTE® NZ supplement is made from New Zealand-sourced materials.

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補助サプリメント

Merck also offers a wide range of other supplements for specific cell culture and in vitrodiagnostics (IVD) applications – for example transferrin, Mod-U-Cyte® and gamma globulin. Designed and produced specifically for biopharmaceutical and IVD customers who operate in a regulated environment, and thus need specific quality and documentation, these supplements round off our portfolio perfectly. As a result, biopharmaceutical companies worldwide rely on us to complete the fundamental nutrition needs of cell culture in their upstream processes.


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