Millipore Sigma Vibrant Logo

506168 p53 Activator VII, STIMA-1 - CAS 91634-12-7 - Calbiochem

The p53 Activator VII, STIMA-1, also referenced under CAS 91634-12-7, modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

p53 Activator VII, STIMA-1 - CAS 91634-12-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 2-Vinyl-1H-quinazolin-4-one, SH group Targeting and Induction of Massive Apoptosis

View This Product on Sigma-Aldrich
506168
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
91634-12-7C₁₀H₈N₂O

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
506168-25MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 25 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA cell-permeable styrylquinazoline compound that preferentially induces apoptotic death of mutant p53-harboring H1299-His175 and Saos-2-His273 tumor cells (IC50 = 3.4 and 4.9 µM, respectively), while exhibiting much reduced potency towards p53-null (IC50 = 9.6, 11.4, and 14.7 µM against H1299, Saos-2, and HCT116, respectively) or wild-type p53-expressing (IC50 = 13.2 and 20.3 µM against HCT116 and HDF, respectively) cells. STIMA-1 is demonstrated to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.
      Catalogue Number506168
      Brand Family Calbiochem®
      Synonyms2-Vinyl-1H-quinazolin-4-one, SH group Targeting and Induction of Massive Apoptosis
      References
      ReferencesZache, N., et al. 2008. Mol. Oncol. 2, 70.
      Product Information
      CAS number91634-12-7
      FormOff-white solid
      Hill FormulaC₁₀H₈N₂O
      Chemical formulaC₁₀H₈N₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at -20°C. Prepare fresh as required.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      506168-25MGCN 04055977272345

      Documentation

      p53 Activator VII, STIMA-1 - CAS 91634-12-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      p53 Activator VII, STIMA-1 - CAS 91634-12-7 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      506168

      参考資料

      参考資料の概要
      Zache, N., et al. 2008. Mol. Oncol. 2, 70.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-December-2010 RFH
      Synonyms2-Vinyl-1H-quinazolin-4-one, SH group Targeting and Induction of Massive Apoptosis
      DescriptionA cell-permeable styrylquinazoline compound that preferentially induces apoptotic death of mutant p53-harboring H1299-His175 and Saos-2-His273 tumor cells (IC50 = 3.4 and 4.9 µM, respectively), while exhibiting much reduced potency towards p53-null (IC50 = 9.6, 11.4, and 14.7 µM against H1299, Saos-2, and HCT116, respectively) or wild-type p53-expressing (IC50 = 13.2 and 20.3 µM against HCT116 and HDF, respectively) cells. STIMA-1 is demonstrated to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number91634-12-7
      Chemical formulaC₁₀H₈N₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at -20°C. Prepare fresh as required.
      Toxicity Standard Handling
      ReferencesZache, N., et al. 2008. Mol. Oncol. 2, 70.