数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

203695 Sigma-AldrichbpV(phen) - CAS 42494-73-5 - Calbiochem

bpV(phen, CAS 42494-73-5, is an insulin mimetic and an inhibitor of protein phosphotyrosine phosphatase. More potent in dephosphorylating of autophosphorylated insulin receptor than orthovanadate.

bpV(phen) - CAS 42494-73-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
カタログ
Data Sheet

同義語: Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII

Primary Target: PTEN

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
42494-73-5	K[VO(O₂)₂C₁₂H₈N₂]

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
203695-10MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	10 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic at 15 µg/kg in vitro and in vivo for use. Inhibits the in situ dephosphorylation of autophosphorylated insulin receptors with over 1000-fold greater potency than sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G₂/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC₅₀ = 38 nM).
Overview	The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
Catalogue Number	203695
Brand Family	Calbiochem®
Synonyms	Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII

References
References	Schmid, A.C., et al. 2004. FEBS Lett. 566, 35. Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421. Drake, P.G., et al. 1996. Endocrinology 137, 4960. Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60. Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784. Yale, J.F., et al. 1995. Diabetes 44, 1274. Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Product Information
CAS number	42494-73-5
ATP Competitive	N
Form	Yellow solid
Hill Formula	K[VO(O₂)₂C₁₂H₈N₂]
Chemical formula	K[VO(O₂)₂C₁₂H₈N₂]
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	bpV(phen, CAS 42494-73-5, is an insulin mimetic and an inhibitor of protein phosphotyrosine phosphatase. More potent in dephosphorylating of autophosphorylated insulin receptor than orthovanadate.

Biological Information
Primary Target	PTEN
Primary Target IC<sub>50</sub>	38 nM
Purity	≥99% by ⁵¹V-NMR

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Unstable in solution; reconstitute just prior to use.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
203695-10MGCN	07790788048365

Documentation

bpV(phen) - CAS 42494-73-5 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

bpV(phen) - CAS 42494-73-5 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
203695	ロット番号を入力

参考資料

参考資料の概要
Schmid, A.C., et al. 2004. FEBS Lett. 566, 35. Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421. Drake, P.G., et al. 1996. Endocrinology 137, 4960. Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60. Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784. Yale, J.F., et al. 1995. Diabetes 44, 1274. Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

カタログ

タイトル
Protein Phosphatases Technical Bulletin

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	15-May-2012 JSW
Synonyms	Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII
Description	A potent insulin receptor kinase (IRK) activator and protein phosphotyrosine phosphatase inhibitor. Excellent insulin mimetic for in vitro and in vivo use (15 µg/kg). Inhibits in situ dephosphorylation of autophosphorylated insulin receptors with greater than 1000-fold potency over sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G₂/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC₅₀ = 38 nM). The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	42494-73-5
Chemical formula	K[VO(O₂)₂C₁₂H₈N₂]
Structure formula
Purity	≥99% by ⁵¹V-NMR
Solubility	H₂O (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Unstable in solution; reconstitute just prior to use.
Toxicity	Standard Handling
References	Schmid, A.C., et al. 2004. FEBS Lett. 566, 35. Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421. Drake, P.G., et al. 1996. Endocrinology 137, 4960. Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60. Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784. Yale, J.F., et al. 1995. Diabetes 44, 1274. Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors

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