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681671 Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem

Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.

Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I

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681671
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
686770-61-6C₂₂H₁₈N₄O₂S₃

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681671-10MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 10 mg
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      Description
      OverviewA cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072).
      Catalogue Number681671
      Brand Family Calbiochem®
      SynonymsInhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I
      References
      ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.
      Product Information
      CAS number686770-61-6
      FormOff-white solid
      Hill FormulaC₂₂H₁₈N₄O₂S₃
      Chemical formulaC₂₂H₁₈N₄O₂S₃
      Quality LevelMQ100
      Applications
      ApplicationWnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-24/25-36-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      681671-10MGCN 04055977225198

      Documentation

      Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      681671

      参考資料

      参考資料の概要
      Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-February-2014 JSW
      SynonymsInhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I
      DescriptionA cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number686770-61-6
      Chemical formulaC₂₂H₁₈N₄O₂S₃
      Purity≥97% by HPLC
      SolubilityDMSO (2.5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.