数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

681535 Sigma-AldrichWithaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem

A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

Primary Target: A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
5119-48-2	C₂₈H₃₈O₆

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
681535-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
681535-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC₅₀ = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC₅₀ = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Catalogue Number	681535
Brand Family	Calbiochem®

References
References	Mohan, R., et al. 2004. Angiogenesis 7, 115. Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125. Devi, P.U., et al. 1995. Cancer Lett. 95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.

Product Information
CAS number	5119-48-2
ATP Competitive	N
Form	White solid
Hill Formula	C₂₈H₃₈O₆
Chemical formula	C₂₈H₃₈O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
Primary Target IC<sub>50</sub>	12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation
Purity	≥94% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	KE7288500

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
681535-1MGCN	04055977260113
681535-5MGCN	04055977260120

Documentation

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
681535	ロット番号を入力

参考資料

参考資料の概要
Mohan, R., et al. 2004. Angiogenesis 7, 115. Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125. Devi, P.U., et al. 1995. Cancer Lett. 95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-September-2008 RFH
Description	A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC₅₀ = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC₅₀ = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	5119-48-2
RTECS	KE7288500
Chemical formula	C₂₈H₃₈O₆
Structure formula
Purity	≥94% by HPLC
Solubility	DMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Mohan, R., et al. 2004. Angiogenesis 7, 115. Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125. Devi, P.U., et al. 1995. Cancer Lett. 95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Angiogenesis Inhibitors > Angiogenesis Inhibitors

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