Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
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96-Well Plate
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その他の試薬を追加 (MAPmatesとともに使用するにはバッファーおよび検出キットが必要です)
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option(チェックを入れると箱詰めから袋詰めに変更となりますのでご注意ください) Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
Ubiquitin E1 Inhibitor, PYR-41, CAS 418805-02-4, is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1 activity (IC50 less than 10 µM in cell-free E1 ubiquitination reactions).
More>>Ubiquitin E1 Inhibitor, PYR-41, CAS 418805-02-4, is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1 activity (IC50 less than 10 µM in cell-free E1 ubiquitination reactions). Less<<
A cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
Ubiquitin E1 Inhibitor, PYR-41, CAS 418805-02-4, is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1 activity (IC50 less than 10 µM in cell-free E1 ubiquitination reactions).
Biological Information
Purity
≥90% by HPLC (sum of two isomers)
Safety Information
R Phrase
R: 36/37/38
Irritating to eyes, respiratory system and skin.
S Phrase
S: 22-24/25-36-45
Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code
Shipped with Blue Ice or with Dry Ice
Toxicity
Irritant
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
Form
Dark purple solid
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₇H₁₃N₃O₇ • 3H₂O
Structure formula
Purity
≥90% by HPLC (sum of two isomers)
Solubility
DMSO (10 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.