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648485 TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.

TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: HC-030031

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648485
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
349085-38-7C₁₈H₂₁N₅O₃

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648485-10MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
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      Description
      OverviewA cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
      Catalogue Number648485
      Brand Family Calbiochem®
      SynonymsHC-030031
      References
      ReferencesTaylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
      McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.
      Product Information
      CAS number349085-38-7
      FormWhite solid
      Hill FormulaC₁₈H₂₁N₅O₃
      Chemical formulaC₁₈H₂₁N₅O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      648485-10MGCN 04055977185058

      Documentation

      TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      648485

      参考資料

      参考資料の概要
      Taylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
      McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-May-2012 JSW
      SynonymsHC-030031
      DescriptionA cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number349085-38-7
      Chemical formulaC₁₈H₂₁N₅O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml; clear, colorless solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTaylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
      McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.