648493 Sigma-AldrichTRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem
The TRPML Agonist, ML-SA1 controls the biological activity of TRPML. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The TRPML Agonist, ML-SA1 controls the biological activity of TRPML. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
同義語: 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1, ML-SA1
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概要
| Replacement Information |
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主要スペック表
| CAS # | Empirical Formula |
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| 332382-54-4 | C₂₂H₂₂N₂O₃ |
価格＆在庫状況
| カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
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| 648493-25MGCN |
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ｶﾞﾗｽﾋﾞﾝ | 25 mg |
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| Description | |
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| Overview | A membrane permeable dihydroquinolinyloxo-isoindolinedione compound that acts as a potent and selective agonist of lysosomal mucolipin transient receptor potential (TRP) channel 1,2,3 (TRPML) in all mammalian cells. Does not appear to affect six other related TRP channels. Shown to rapidly activate whole-endolysosome TRPML-like current and induce lysosomal Ca2+ release (~10 µM). Its activating action on whole-endolysosome is comparable to that of PI(3,5)P2 (1 µM) with which it shows a synergistic effect. ML-SA1-induced Ca2+ responses are reportedly abolished by glycyl-L-phenylalanine 2-naphthylamide, induces osmotic lysis of lysosomes, and Bafilomycin A1 (Cat. No. 196000), a V-ATPase inhibitor. Also reduces lactosylceramide and cholesterol accumulation and corrects trafficking defects in Niemann-Pick (NP) disease cells. |
| Catalogue Number | 648493 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1, ML-SA1 |
| References | |
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| References | Shen, D., et al. 2012. Nat. Commun. 3, 731. |
| Product Information | |
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| CAS number | 332382-54-4 |
| Form | Off-white powder |
| Hill Formula | C₂₂H₂₂N₂O₃ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | TRPML1,2,3 |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| カタログ番号 | GTIN |
| 648493-25MGCN | 04055977185089 |
Documentation
TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem (M)SDS
| タイトル |
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TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem 試験成績書（CoA）
| タイトル | ロット番号 |
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| 648493 |
参考資料
| 参考資料の概要 |
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| Shen, D., et al. 2012. Nat. Commun. 3, 731. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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