530796 Sigma-AldrichTNF-TNFR Interaction Modulator, C87 - CAS 332420-90-3 - Calbiochem
Inhibits TNFα/β-stimulated biological activity by modulating, but not abolishing, TNF-TNFR interaction via direct TNF affinity interaction (KD = 110 nM).
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同義語: (E)-4-(2-(4-Chloro-3-nitrophenyl)hydrazono)-3-phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one, (E)-4-(2-(4-Chloro-3-nitrophenyl)), TNF-TNFR Signaling Inhibitor IV
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概要
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主要スペック表
| CAS # | Empirical Formula |
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| 332420-90-3 | C₂₄H₁₅ClN₆O₃S |
価格＆在庫状況
| カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
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| 5.30796.0001 |
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ｶﾞﾗｽﾋﾞﾝ | 10 mg |
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| Description | |
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| Overview | A phenylhydrazonodihydropyrazolone compound that inhibits TNFα/β-stimulated biological activity by modulating, but not abolishing, TNF-TNFR interaction via direct TNF affinity interaction (KD = 110 nM). Shown to prevent murine L929 cell death following hTNFα/β (1 ng/mL; Cat. Nos. 654205 & 654215) and actinomycin D (1 µg/mL; Cat. Nos. 114666 & 2472-OP) treatment (EC50 = 8.73 µM) by blocking TNF/ActD-induced caspase-3/8 cleavages & IκBα degradation without affecting Fas- (CD95) mediated Jurkat cell death or VP-16 (Etoposide; Cat. No. 341205) and ADR (Adriamycin/Doxorubicin; Cat. No. 324380) cytotoxicity in L292 cultures. When applied prior to D-galactosamine (1.2 g D-GalN/kg, Cat. No. 34539) & Lipopolysaccharide (LPS; 50 µg/kg) injection, C87 effectively prevents D-GalN/LPS-induced upregulation of plasma alanine transaminase & aspartate transaminase (ALT & AST) activity, resulting in significantly reduced liver damage and much improved survival rate (3X 12.5 mg C87/kg i.p. dosings 16, 8, & 1 h prior to D-GalN/LPS injection) in a murine hepatitis model in vivo. |
| Catalogue Number | 530796 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-4-(2-(4-Chloro-3-nitrophenyl)hydrazono)-3-phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one, (E)-4-(2-(4-Chloro-3-nitrophenyl)), TNF-TNFR Signaling Inhibitor IV |
| References | |
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| References | Ma, L., et al. 2014. J. Biol. Chem. 289, 12457. |
| Product Information | |
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| CAS number | 332420-90-3 |
| Form | Dark red solid |
| Hill Formula | C₂₄H₁₅ClN₆O₃S |
| Chemical formula | C₂₄H₁₅ClN₆O₃S |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | TNFα |
| Primary Target K<sub>i</sub> | 110 nM for hTNF&alpha |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| カタログ番号 | GTIN |
| 5.30796.0001 | 04055977242973 |
Documentation
TNF-TNFR Interaction Modulator, C87 - CAS 332420-90-3 - Calbiochem (M)SDS
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参考資料
| 参考資料の概要 |
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| Ma, L., et al. 2014. J. Biol. Chem. 289, 12457. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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