613551 Sigma-AldrichTMEM16A Inhibitor, T16Ainh-A01 - Calbiochem
TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).
More>> TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Less<<TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
同義語: ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
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概要
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主要スペック表
| CAS # | Empirical Formula |
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| 552309-42-9 | C₁₉H₂₀N₄O₃S₂ |
価格＆在庫状況
| カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
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| 613551-5MGCN |
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ｶﾞﾗｽﾋﾞﾝ | 5 mg |
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| Description | |
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| Overview | An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels. |
| Catalogue Number | 613551 |
| Brand Family | Calbiochem® |
| Synonyms | ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01 |
| References | |
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| References | Davis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press Namkung, W., et al. 2011., J Biol Chem. in press. Namkung, W., et al. 2011., FASEB J. in press. |
| Product Information | |
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| CAS number | 552309-42-9 |
| Form | Off-white powder |
| Hill Formula | C₁₉H₂₀N₄O₃S₂ |
| Chemical formula | C₁₉H₂₀N₄O₃S₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). |
| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| カタログ番号 | GTIN |
| 613551-5MGCN | 04055977263824 |
Documentation
TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem (M)SDS
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TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem 試験成績書（CoA）
| タイトル | ロット番号 |
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| 613551 |
参考資料
| 参考資料の概要 |
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| Davis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press Namkung, W., et al. 2011., J Biol Chem. in press. Namkung, W., et al. 2011., FASEB J. in press. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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