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616454 TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem

TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).

TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV

Primary Target: ALK-4/5/7
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616454
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概要

主要スペック表

CAS #Empirical Formula
909910-43-6C₂₅H₁₉N₅S

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      Description
      OverviewA cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
      Catalogue Number616454
      Brand Family Calbiochem®
      SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
      References
      ReferencesTojo, M., et al. 2005. Cancer Sci. 96, 791.
      Product Information
      CAS number909910-43-6
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₂₅H₁₉N₅S
      Chemical formulaC₂₅H₁₉N₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Biological Information
      Primary TargetALK-4/5/7
      Primary Target IC<sub>50</sub>45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      カタログ番号 GTIN
      616454-2MGCN 04055977185867