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574102 Sulindac Sulfide - CAS 32004-67-4 - Calbiochem

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574102
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概要

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CAS #Empirical Formula
32004-67-4C₂₀H₁₇FO₂S

価格&在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
574102-5MGCN
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現在国内在庫なし
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現在国内在庫あり
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      樹脂アンプル 5 mg
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      Description
      OverviewA cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L.
      Catalogue Number574102
      Brand Family Calbiochem®
      Synonyms(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
      References
      ReferencesWeggen, S., et al. 2001. Nature 414, 212.
      Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
      Herrmann, C., et al. 1998. Oncogene 17, 1769.
      Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
      Arber, N., et al. 1997. Gastroenterology 113, 1892.
      Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
      Product Information
      CAS number32004-67-4
      ATP CompetitiveN
      FormYellow-orange solid
      Hill FormulaC₂₀H₁₇FO₂S
      Chemical formulaC₂₀H₁₇FO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCOX-1
      Primary Target IC<sub>50</sub>ID50 = 500 nM against COX-1
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 22-42/43-63

      Harmful if swallowed.
      May cause sensitization by inhalation and skin contact.
      Possible risk of harm to the unborn child.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Global Trade Item Number
      カタログ番号 GTIN
      574102-5MGCN 04055977189551