数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

569397 Sigma-AldrichStaurosporine, Streptomyces sp.

Staurosporine, CAS 62996-74-, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinases (IC₅₀ = 7, 20, 1.3, 0.7, & 8.5 nM for PKA, CAMK, MLCK, PKC, & PKG, respectively).

Staurosporine, Streptomyces sp.: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
カタログ
Data Sheet
Citations

同義語: MLCK Inhibitor I, PKA Inhibitor II

Primary Target: PKA

View This Product on Sigma-Aldrich

お勧めの製品

概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
62996-74-1	C₂₈H₂₆N₄O₃

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
569397-100UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	100 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
569397-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
569397-250UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	250 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein kinase A (IC₅₀ = 7 nM), CaM kinase (IC₅₀ = 20 nM), myosin light chain kinase (IC₅₀ = 1.3 nM), protein kinase C (IC₅₀ = 700 pM), and protein kinase G (IC₅₀ = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G₁ checkpoint. A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569396) in DMSO is also available.
Catalogue Number	569397
Brand Family	Calbiochem®
Synonyms	MLCK Inhibitor I, PKA Inhibitor II

References
References	Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43. Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271. Bruno, S., et al. 1992. Cancer Res. 52, 470. Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853. Vitale, M.L., et al. 1992. Neuroscience 51, 463. Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102. Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.

References

Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
Bruno, S., et al. 1992. Cancer Res. 52, 470.
Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
Vitale, M.L., et al. 1992. Neuroscience 51, 463.
Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102.
Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.

Product Information
CAS number	62996-74-1
ATP Competitive	Y
Form	White to pale yellow solid
Hill Formula	C₂₈H₂₆N₄O₃
Chemical formula	C₂₈H₂₆N₄O₃
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PKA
Primary Target IC<sub>50</sub>	7 nM, 20 nM, 1.3 nM, 700 pM, and 8.5 nM against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
569397-100UGCN	07790788057855
569397-1MGCN	04055977190465
569397-250UGCN	04055977190496

Documentation

Staurosporine, Streptomyces sp. (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Staurosporine, Streptomyces sp. 試験成績書（CoA）

タイトル	ロット番号
569397	ロット番号を入力

参考資料

参考資料の概要
Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43. Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271. Bruno, S., et al. 1992. Cancer Res. 52, 470. Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853. Vitale, M.L., et al. 1992. Neuroscience 51, 463. Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102. Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.

参考資料の概要

カタログ

タイトル
Caspases and other Apoptosis Related Tools Brochure
Protein Kinase Assay and Detection Kits Brochure
Tools and Tips for Analyzing Apoptosis

引用

Title

Joao B. Oliveira, et al. (2007) NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Procedings of the National Academy of Science 104, 8953-8958.

Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.

Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-July-2014 JSW
Synonyms	MLCK Inhibitor I, PKA Inhibitor II
Description	A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC₅₀ = 20 nM), myosin light chain kinase (IC₅₀ = 1.3 nM), protein kinase A (IC₅₀ = 7 nM), protein kinase C (IC₅₀ = 0.7 nM), and protein kinase G (IC₅₀ = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G₁ checkpoint.
Form	White to pale yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	62996-74-1
Chemical formula	C₂₈H₂₆N₄O₃
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (5 mg/ml). Further dilute with aqueous buffers just prior to use.
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
Toxicity	Standard Handling
References	Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43. Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271. Bruno, S., et al. 1992. Cancer Res. 52, 470. Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853. Vitale, M.L., et al. 1992. Neuroscience 51, 463. Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102. Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
Citation	Joao B. Oliveira, et al. (2007) NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Procedings of the National Academy of Science 104, 8953-8958. Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530. Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors

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