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567732 Sphingosine Kinase 1 Inhibitor, SKI-178 - Calbiochem

Sphingosine Kinase 1 Inhibitor, SKI-178 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide

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567732
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概要

Replacement Information

主要スペック表

Empirical Formula
C₂₁H₂₂N₄O₄

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567732-10MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
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      Description
      OverviewA cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µM).
      Catalogue Number567732
      Brand Family Calbiochem®
      SynonymsNʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide
      References
      ReferencesHengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett. 20, 7498
      Product Information
      FormOff-white powder
      Hill FormulaC₂₁H₂₂N₄O₄
      Chemical formulaC₂₁H₂₂N₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥92% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      567732-10MGCN 04055977190861

      Documentation

      Sphingosine Kinase 1 Inhibitor, SKI-178 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Sphingosine Kinase 1 Inhibitor, SKI-178 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      567732

      参考資料

      参考資料の概要
      Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett. 20, 7498
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-February-2013 JSW
      SynonymsNʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide
      DescriptionA cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µM).
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₂₂N₄O₄
      Structure formulaStructure formula
      Purity≥92% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett. 20, 7498