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567565 Sodium Stibogluconate - CAS 16037-91-5 - Calbiochem

Sodium Stibogluconate, CAS 16037-91-5, is a pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase activity, including SHP-1, by forming a stable complex.

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同義語: SSG, Antimony Sodium Gluconate, NaSbv, PTP Inhibitor XXIV, SHP1 Inhibitor IV

Primary Target: PTPase activity, including Src homology PTPase-1 (SHP-1)
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567565
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
16037-91-5C₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O

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      Description
      OverviewA pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex. At higher concentrations (~110 µM), it inhibits SHP-2 and PTP1B activities.
      Catalogue Number567565
      Brand Family Calbiochem®
      SynonymsSSG, Antimony Sodium Gluconate, NaSbv, PTP Inhibitor XXIV, SHP1 Inhibitor IV
      References
      ReferencesWortmann, G., et al. 2002. Clin. Infect. Dis. 35, 261.
      Pathak, M.K. and Yi, T. 2001. J. Immunol. 167, 3391.
      Product Information
      CAS number16037-91-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
      Chemical formulaC₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSodium Stibogluconate, CAS 16037-91-5, is a pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase activity, including SHP-1, by forming a stable complex.
      Biological Information
      Primary TargetPTPase activity, including Src homology PTPase-1 (SHP-1)
      Primary Target IC<sub>50</sub>~11 µM causing 99% inhibition of protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1)
      Purity≥90% by titration on dry basis (≥30% Sb content)
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      567565-1GMCN 07790788051648

      Documentation

      Sodium Stibogluconate - CAS 16037-91-5 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Sodium Stibogluconate - CAS 16037-91-5 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      567565

      参考資料

      参考資料の概要
      Wortmann, G., et al. 2002. Clin. Infect. Dis. 35, 261.
      Pathak, M.K. and Yi, T. 2001. J. Immunol. 167, 3391.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-June-2008 RFH
      SynonymsSSG, Antimony Sodium Gluconate, NaSbv, PTP Inhibitor XXIV, SHP1 Inhibitor IV
      DescriptionA pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µM). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µM). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (ECmax = 44 µM) and GM-CSF-induced proliferation in TF-1 cells (ECmax = 55 µM). Exhibits anti-leishmanial effects.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number16037-91-5
      Chemical formulaC₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
      Structure formulaStructure formula
      Purity≥90% by titration on dry basis (≥30% Sb content)
      SolubilityH₂O (1 mg/ml). Heating to 75°C with constant stirring or constant stirring overnight at room temperature may be required for complete solubilization.
      Storage Protect from moisture
      Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      Merck USA index14, 701
      ReferencesWortmann, G., et al. 2002. Clin. Infect. Dis. 35, 261.
      Pathak, M.K. and Yi, T. 2001. J. Immunol. 167, 3391.