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566405 Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem

Smad3 Inhibitor, SIS3, CAS 1009104-85-1, is a cell-permeable, selective inhibitor of TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated signaling. Does not affect Smad2, MAPK, ERK, or PI3-K.

Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: SIS3, 6,7-Dimethoxy-2-((2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-prop-2-enoyl))-1,2,3,4-tetrahydroisoquinoline, Specific Inhibitor of Smad3

Primary Target: TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling
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566405
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
1009104-85-1C₂₈H₂₇N₃O₃

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566405-1MGCN
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      Description
      OverviewA cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling.
      Catalogue Number566405
      Brand Family Calbiochem®
      SynonymsSIS3, 6,7-Dimethoxy-2-((2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-prop-2-enoyl))-1,2,3,4-tetrahydroisoquinoline, Specific Inhibitor of Smad3
      References
      ReferencesJinnin, M., et al. 2006. Mol. Pharmacol. 69, 597.
      Product Information
      CAS number1009104-85-1
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₈H₂₇N₃O₃
      Chemical formulaC₂₈H₂₇N₃O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      566405-1MGCN 04055977191516

      Documentation

      Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      566405

      参考資料

      参考資料の概要
      Jinnin, M., et al. 2006. Mol. Pharmacol. 69, 597.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsSIS3, 6,7-Dimethoxy-2-((2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-prop-2-enoyl))-1,2,3,4-tetrahydroisoquinoline, Specific Inhibitor of Smad3
      DescriptionA cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1009104-85-1
      Chemical formulaC₂₈H₂₇N₃O₃
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (15 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesJinnin, M., et al. 2006. Mol. Pharmacol. 69, 597.