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565850 Shikonin - CAS 517-89-5 - Calbiochem

A naphthoquinone found in the Chinese herb Shiunko.

Shikonin - CAS 517-89-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Pyruvate Kinase Inhibitor II

Primary Target: TNF-α-induced and B-16 melanoma-induced angiogenesis
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565850
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
517-89-5C₁₆H₁₆O₅

価格＆在庫状況

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565850-10MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 10 mg
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      Description
      OverviewA naphthoquinone found in the Chinese herb Shiunko. Possesses significant antibacterial, anti-inflammatory, and antitumor activities. Inhibits TNF-α-induced and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line.
      Catalogue Number565850
      Brand Family Calbiochem®
      SynonymsPyruvate Kinase Inhibitor II
      References
      ReferencesChen, J., et al. 2011. Oncogene 30, 4297.
      Li, H., et al. 1999. Phytother. Res. 13, 236.
      Yoon, Y., et al. 1999. Planta Med. 65, 532.
      Hisa, T., et al. 1998. Anticancer Res. 18, 783.
      Product Information
      CAS number517-89-5
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₁₆H₁₆O₅
      Chemical formulaC₁₆H₁₆O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α-induced and B-16 melanoma-induced angiogenesis
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQL8000200
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      565850-10MGCN 04055977191943

      Documentation

      Shikonin - CAS 517-89-5 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Shikonin - CAS 517-89-5 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      565850

      参考資料

      参考資料の概要
      Chen, J., et al. 2011. Oncogene 30, 4297.
      Li, H., et al. 1999. Phytother. Res. 13, 236.
      Yoon, Y., et al. 1999. Planta Med. 65, 532.
      Hisa, T., et al. 1998. Anticancer Res. 18, 783.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      SynonymsPyruvate Kinase Inhibitor II
      DescriptionA naphthoquinone found in the Chinese herb Lithospermum erythrorhizon. Possesses significant antibacterial, anti-inflammatory and antitumor activities. Inhibits TNF-α and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αVβ3 and inhibits endothelial cells proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line. Selectively blocks PKM2 (IC50 <1 µM) over PKM1 and PKL activities (IC50 in the range of 10-20 µM), and inhibits cancer cell glycolysis.
      FormRed solid
      CAS number517-89-5
      RTECSQL8000200
      Chemical formulaC₁₆H₁₆O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, J., et al. 2011. Oncogene 30, 4297.
      Li, H., et al. 1999. Phytother. Res. 13, 236.
      Yoon, Y., et al. 1999. Planta Med. 65, 532.
      Hisa, T., et al. 1998. Anticancer Res. 18, 783.