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573128 STAT3 Inhibitor XIII, C188-9 - CAS 432001-19-9 - Calbiochem

The Stat3 Inhibitor XIII, C188-9 controls the biological activity of Stat3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

STAT3 Inhibitor XIII, C188-9 - CAS 432001-19-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: N-(1ʹ,2-Dihydroxy-1,2ʹ-binaphthalen-4ʹ-yl)-4-methoxybenzenesulfonamide, F1113-0789

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573128
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
432001-19-9C₂₇H₂₁NO₅S

価格＆在庫状況

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573128-10MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
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      Description
      OverviewA cell-permeable binaphthol-sulfonamide that competes against pY proteins for Stat3 SH2 domain binding. Shown to inhibit G-CSF-induced Stat3 tyr705 phosphorylation in human AML cell lines and primary cultures (IC50 from 4.1 to 18 µM). Also shown to inhibit G-CSF-stimulated TIE2, MATK, JAK1, and HGFR phosphorylation (by 90%, 50%, 40%, and 40%, respectively; 10 µM C188-9), but not 15 other phosphoproteins (≤30% inhibition), including pERK1/2 and pAKT, in Kasumi-1 cells.
      Catalogue Number573128
      Brand Family Calbiochem®
      SynonymsN-(1ʹ,2-Dihydroxy-1,2ʹ-binaphthalen-4ʹ-yl)-4-methoxybenzenesulfonamide, F1113-0789
      References
      ReferencesRedell, M.S., et al. 2011. Blood 112, 355.
      Product Information
      CAS number432001-19-9
      FormOff-white to pale beige powder
      Hill FormulaC₂₇H₂₁NO₅S
      Chemical formulaC₂₇H₂₁NO₅S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      573128-10MGCN 04055977190182

      Documentation

      STAT3 Inhibitor XIII, C188-9 - CAS 432001-19-9 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      STAT3 Inhibitor XIII, C188-9 - CAS 432001-19-9 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      573128

      参考資料

      参考資料の概要
      Redell, M.S., et al. 2011. Blood 112, 355.

      カタログ

      タイトル
      New Products: Volume 3, 2012

      技術情報

      タイトル
      JAK/STAT Signaling Research Focus
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-April-2012 JSW
      SynonymsN-(1ʹ,2-Dihydroxy-1,2ʹ-binaphthalen-4ʹ-yl)-4-methoxybenzenesulfonamide, F1113-0789
      DescriptionA cell-permeable binaphthol-sulfonamide that competes against pY proteins for Stat3 SH2 domain binding. Shown to inhibit G-CSF-induced (100 ng/ml for 15 min following 1 h drug pretreatment) Stat3 tyr705 phosphorylation in 6 human AML cell lines (IC50 from 4.1 to 8.3 µM) and 4 primary pediatric AML cultures (IC50 from 8 to 18 µM). Long-term treatments (24 h for lines and 48 h for primary cultures) result in apoptosis induction (Annexin V-PE staining) in 7 AML lines (EC50 from 8.4 to 43.6 µM) and CD34+ populations from 5 primary pediatric AML samples (EC50 from 0.8 to25 µM). Selectivity studies using Kasumi-1 cells reveals concomitant inhibitions of G-CSF-stimulated TIE2, MATK, JAK1, and HGFR phosphorylation (by 90%, 50%, 40%, and 40%, respectively; 10 µM C188-9), but not 15 other phosphoproteins (≤30% inhibition), including pERK1/2 and pAKT.
      FormOff-white to pale beige powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number432001-19-9
      Chemical formulaC₂₇H₂₁NO₅S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Toxic
      ReferencesRedell, M.S., et al. 2011. Blood 112, 355.