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573099 STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem

STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.

STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

Primary Target: STAT3
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573099
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
19983-44-9C₈H₅NO₄S

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573099-25MGCN
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      Description
      OverviewA cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
      Catalogue Number573099
      Brand Family Calbiochem®
      Synonyms6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
      References
      ReferencesSchust, J., et al. 2006. Chem. Biol. 13, 1235.
      Product Information
      CAS number19983-44-9
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₈H₅NO₄S
      Chemical formulaC₈H₅NO₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSTAT3
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      573099-25MGCN 07790788051754

      Documentation

      STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      573099

      参考資料

      参考資料の概要
      Schust, J., et al. 2006. Chem. Biol. 13, 1235.

      カタログ

      タイトル
      Pathways and Biomarkers of JAK/STAT Signaling

      技術情報

      タイトル
      JAK/STAT Signaling Research Focus
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-June-2007 JSW
      Synonyms6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
      DescriptionA cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number19983-44-9
      Chemical formulaC₈H₅NO₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
      Toxicity Irritant
      ReferencesSchust, J., et al. 2006. Chem. Biol. 13, 1235.