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566322 SIRT1 Inhibitor III

The SIRT1 Inhibitor III, also referenced under CAS 49843-98-3, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications.

SIRT1 Inhibitor III: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527

Primary Target: SIRT1
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566322
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概要

主要スペック表

CAS #Empirical Formula
49843-98-3C₁₃H₁₃ClN₂O

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566322-5MGCN
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      Description
      OverviewA cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.
      Catalogue Number566322
      Brand Family Calbiochem®
      Synonyms6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527
      References
      ReferencesSolomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.
      Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.
      Product Information
      CAS number49843-98-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₃H₁₃ClN₂O
      Chemical formulaC₁₃H₁₃ClN₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetSIRT1
      Primary Target IC<sub>50</sub>98 nM against SIRT1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      カタログ番号 GTIN
      566322-5MGCN 04055977191394