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559410 SB 290157 - CAS 1140525-25-2 - Calbiochem

SB 290157, CAS 1140525-25-2, is a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic GPCRs.

SB 290157 - CAS 1140525-25-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: N²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA

Primary Target: C3a receptor
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559410
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概要

主要スペック表

CAS #Empirical Formula
1140525-25-2C₂₂H₂₈N₄O₄ · CF₃CO₂H

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      Description
      OverviewA non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic G-protein-coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC50 = 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from Guinea pig platelets (IC50 = 30 nM). Exhibits anti-inflammatory properties. Supplied as a trifluoroacetate salt.
      Catalogue Number559410
      Brand Family Calbiochem®
      SynonymsN²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA
      References
      ReferencesAmes, R.S., et al. 2001. J. Immunol. 166, 6341.
      Product Information
      CAS number1140525-25-2
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
      Chemical formulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSB 290157, CAS 1140525-25-2, is a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic GPCRs.
      Biological Information
      Primary TargetC3a receptor
      Primary Target IC<sub>50</sub>200 nM against the anaphylatoxin C3a receptor; 7, 12.5, and 27.7 nM, in blocking C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Do not reuse solutions diluted in physiological buffers.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      カタログ番号 GTIN
      559410-10MGCN 04055977268140