数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

559396 Sigma-AldrichSB 220025

A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC₅₀ = 60 nM).

SB 220025: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV

Primary Target: P38MAPK

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
165806-53-1	C₁₈H₁₉FN₆

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
559396-500UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	500 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC₅₀ = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	559396
Brand Family	Calbiochem®
Synonyms	5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV

References
References	Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687. Wang, Z., et al. 1998. Structure 6, 1117.

Product Information
CAS number	165806-53-1
Form	White to pale yellow solid
Hill Formula	C₁₈H₁₉FN₆
Chemical formula	C₁₈H₁₉FN₆
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	P38MAPK
Primary Target IC<sub>50</sub>	60 nM
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
559396-500UGCN	07790788051549

Documentation

SB 220025 (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

SB 220025 試験成績書（CoA）

タイトル	ロット番号
559396	ロット番号を入力

参考資料

参考資料の概要
Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687. Wang, Z., et al. 1998. Structure 6, 1117.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-November-2014 JSW
Synonyms	5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
Description	A potent and specific inhibitor of human p38 mitogen-activated protein (MAP) kinase (IC₅₀ = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits >2500-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1600-fold over EGFRK. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
Form	White to pale yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	165806-53-1
Chemical formula	C₁₈H₁₉FN₆
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (22 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687. Wang, Z., et al. 1998. Structure 6, 1117.

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