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559395 SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem

SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor XVI, Hydrochloride

Primary Target: p38 MAP kinase
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559395
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
869185-85-3C₂₁H₁₆FN₃OS · HCl

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
559395-10MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 10 mg
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      559395-1MGCN
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          		 樹脂ｱﾝﾌﾟﾙ 1 mg
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          Description
          OverviewA water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
          Catalogue Number559395
          Brand Family Calbiochem®
          Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor XVI, Hydrochloride
          References
          Product Information
          CAS number869185-85-3
          ATP CompetitiveN
          FormBright yellow solid
          Hill FormulaC₂₁H₁₆FN₃OS · HCl
          Chemical formulaC₂₁H₁₆FN₃OS · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetp38 MAP kinase
          Primary Target IC<sub>50</sub>34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          559395-10MGCN 04055977192575
          559395-1MGCN 04055977192568

          Documentation

          SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          559395

          引用

          Title
        • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
        • Guadalupe Sabio, et al. (2005) p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. The EMBO Journal 24, 1134-1145.
        • Jose G. Trevino, et al. (2005) Expression and activity of Src regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Research 65, 7214-7222.
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
          		•
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor XVI, Hydrochloride
          DescriptionA water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
          FormBright yellow solid
          CAS number869185-85-3
          Chemical formulaC₂₁H₁₆FN₃OS · HCl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO or H₂O (10 mg/ml)
          Storage Protect from light
          -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          Citation
        • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
        • Guadalupe Sabio, et al. (2005) p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. The EMBO Journal 24, 1134-1145.
        • Jose G. Trevino, et al. (2005) Expression and activity of Src regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Research 65, 7214-7222.
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
          		•

          関連製品＆アプリケーション

          Alternative Products

          カタログ番号 説明  
          559389 SB 203580 - CAS 152121-47-6 - Calbiochem 価格＆在庫状況を表示

          カテゴリー

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors