559303 Sigma-AldrichSANT-1 - CAS 304909-07-7 - Calbiochem
A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors.
More>> A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors. Less<<同義語: Shh Signaling Antagonist V
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概要
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主要スペック表
CAS # | Empirical Formula |
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304909-07-7 | C₂₃H₂₇N₅ |
価格&在庫状況
カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
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559303-5MGCN |
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樹脂アンプル | 5 mg |
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Description | |
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Overview | A potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells) by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay). |
Catalogue Number | 559303 |
Brand Family | Calbiochem® |
Synonyms | Shh Signaling Antagonist V |
References | |
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References | Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. |
Product Information | |
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CAS number | 304909-07-7 |
ATP Competitive | N |
Form | White solid |
Hill Formula | C₂₃H₂₇N₅ |
Chemical formula | C₂₃H₂₇N₅ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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カタログ番号 | GTIN |
559303-5MGCN | 04055977192414 |
Documentation
SANT-1 - CAS 304909-07-7 - Calbiochem (M)SDS
タイトル |
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SANT-1 - CAS 304909-07-7 - Calbiochem 試験成績書(CoA)
タイトル | ロット番号 |
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559303 |
参考資料
参考資料の概要 |
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Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. |