Millipore Sigma Vibrant Logo

553509 Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

Ras/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.

Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline

Primary Target: Ras/Rac
View This Product on Sigma-Aldrich
553509
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
171927-40-5C₁₆H₂₀N₄O₃

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
553509-10MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 10 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
      Catalogue Number553509
      Brand Family Calbiochem®
      Synonyms6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
      References
      ReferencesHuber, K. V. M., et al. 2014. Nature In press.
      He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
      Walsh, A.B., et al. 1997. Oncogene 15, 2553.
      Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.
      Product Information
      CAS number171927-40-5
      ATP CompetitiveN
      FormLight-yellow solid
      Hill FormulaC₁₆H₂₀N₄O₃
      Chemical formulaC₁₆H₂₀N₄O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationRas/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.
      Biological Information
      Primary TargetRas/Rac
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      553509-10MGCN 04055977193688

      Documentation

      Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      553509

      参考資料

      参考資料の概要
      Huber, K. V. M., et al. 2014. Nature In press.
      He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
      Walsh, A.B., et al. 1997. Oncogene 15, 2553.
      Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2014 JSW
      Synonyms6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
      DescriptionA cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
      FormLight-yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number171927-40-5
      Chemical formulaC₁₆H₂₀N₄O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHuber, K. V. M., et al. 2014. Nature In press.
      He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
      Walsh, A.B., et al. 1997. Oncogene 15, 2553.
      Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.