Millipore Sigma Vibrant Logo

553210 Rapamycin - CAS 53123-88-9 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 553210) on sigmaaldrich.com.

Rapamycin - CAS 53123-88-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: mTOR Inhibitor I

Primary Target: Mammalian target of rapamycin (mTOR)
View This Product on Sigma-Aldrich
553210
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
53123-88-9C₅₁H₇₉NO₁₃

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
553210-100UGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 100 μg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      553210-10MGCN
      在庫状況検索中…
      —
      現在国内在庫なし 現在国内在庫なし
      現在国内在庫有り 
      販売中止
      在庫僅少
      現在国内在庫あり
        Remaining : Will advise
          Remaining : Will advise
          注文対象外
          お問合せください
          Contact Customer Service

          		 ｶﾞﾗｽﾋﾞﾝ 10 mg
          価格を検索中…
          価格が見つかりません
          Minimum Quantity needs to be mulitiple of
          Maximum Quantity is
          弊社照会 詳細を表示　
          値引
          ()
           
          —
          弊社照会
          		 —
          553210-1MGCN
          在庫状況検索中…
          —
          現在国内在庫なし 現在国内在庫なし
          現在国内在庫有り 
          販売中止
          在庫僅少
          現在国内在庫あり
            Remaining : Will advise
              Remaining : Will advise
              注文対象外
              お問合せください
              Contact Customer Service

              		 樹脂ｱﾝﾌﾟﾙ 1 mg
              価格を検索中…
              価格が見つかりません
              Minimum Quantity needs to be mulitiple of
              Maximum Quantity is
              弊社照会 詳細を表示　
              値引
              ()
               
              —
              弊社照会
              		 —
              553210-5MGCN
              在庫状況検索中…
              —
              現在国内在庫なし 現在国内在庫なし
              現在国内在庫有り 
              販売中止
              在庫僅少
              現在国内在庫あり
                Remaining : Will advise
                  Remaining : Will advise
                  注文対象外
                  お問合せください
                  Contact Customer Service

                  		 ｶﾞﾗｽﾋﾞﾝ 5 mg
                  価格を検索中…
                  価格が見つかりません
                  Minimum Quantity needs to be mulitiple of
                  Maximum Quantity is
                  弊社照会 詳細を表示　
                  値引
                  ()
                   
                  —
                  弊社照会
                  		 —
                  Description
                  OverviewAnti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
                  Catalogue Number553210
                  Brand Family Calbiochem®
                  SynonymsmTOR Inhibitor I
                  References
                  ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
                  Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
                  Braun, W., et al. 1995. FASEB J. 9, 63.
                  Nielsen, F.C., et al. 1995. Nature 377, 358.
                  Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
                  Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
                  Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
                  Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
                  Kuo, J., et al. 1992. Nature 358, 70.
                  Price, D.J., et al. 1992. Science 257, 973.
                  Heitman, J., et al. 1991. Science 253, 905.
                  Kay, J.E., et al. 1991. Immunology 72, 544.
                  Schreiber, S.L. 1991. Science 251, 283.
                  Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
                  Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
                  Product Information
                  CAS number53123-88-9
                  ATP CompetitiveN
                  FormClear film
                  Hill FormulaC₅₁H₇₉NO₁₃
                  Chemical formulaC₅₁H₇₉NO₁₃
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ200
                  Applications
                  Biological Information
                  Primary TargetMammalian target of rapamycin (mTOR)
                  Primary Target IC<sub>50</sub>50 pM against p70 S6 kinase
                  Purity≥99% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSVE6250000
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage -20°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Global Trade Item Number
                  カタログ番号 GTIN
                  553210-100UGCN 04055977193510
                  553210-10MGCN 07790788060305
                  553210-1MGCN 04055977193480
                  553210-5MGCN 04055977193534

                  Documentation

                  Rapamycin - CAS 53123-88-9 - Calbiochem (M)SDS

                  タイトル

                  英語版製品安全データシート（(M)SDS） 

                  Rapamycin - CAS 53123-88-9 - Calbiochem 試験成績書（CoA）

                  タイトルロット番号
                  553210

                  参考資料

                  参考資料の概要
                  Chen, T., et al. 2011. Aging Cell. 10, 908.
                  Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
                  Braun, W., et al. 1995. FASEB J. 9, 63.
                  Nielsen, F.C., et al. 1995. Nature 377, 358.
                  Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
                  Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
                  Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
                  Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
                  Kuo, J., et al. 1992. Nature 358, 70.
                  Price, D.J., et al. 1992. Science 257, 973.
                  Heitman, J., et al. 1991. Science 253, 905.
                  Kay, J.E., et al. 1991. Immunology 72, 544.
                  Schreiber, S.L. 1991. Science 251, 283.
                  Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
                  Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

                  カタログ

                  タイトル
                  Bulk Product Guide
                  Caspases and other Apoptosis Related Tools Brochure

                  データシート

                  タイトル
                  Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

                  Posters

                  タイトル
                  Human Kinome & InhibitorSelect™ Libraries

                  引用

                  Title
                • Chen, T., et al. 2011. Aging Cell. 10, 908.
                • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
                • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
                • Liao, X., et al. 2003. Endocrinology 144, 1656.
                  		•
                  データシート

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision11-September-2014 JSW
                  SynonymsmTOR Inhibitor I
                  DescriptionSelectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
                  FormClear film
                  CAS number53123-88-9
                  RTECSVE6250000
                  Chemical formulaC₅₁H₇₉NO₁₃
                  Structure formulaStructure formula
                  Purity≥99% by HPLC
                  SolubilityDMSO (200 mg/ml) or Ethanol (50 mg/ml)
                  Storage -20°C
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Toxicity Standard Handling
                  Merck USA index14, 8114
                  ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
                  Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
                  Braun, W., et al. 1995. FASEB J. 9, 63.
                  Nielsen, F.C., et al. 1995. Nature 377, 358.
                  Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
                  Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
                  Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
                  Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
                  Kuo, J., et al. 1992. Nature 358, 70.
                  Price, D.J., et al. 1992. Science 257, 973.
                  Heitman, J., et al. 1991. Science 253, 905.
                  Kay, J.E., et al. 1991. Immunology 72, 544.
                  Schreiber, S.L. 1991. Science 251, 283.
                  Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
                  Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
                  Citation
                • Chen, T., et al. 2011. Aging Cell. 10, 908.
                • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
                • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
                • Liao, X., et al. 2003. Endocrinology 144, 1656.
                  		•