数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

553400 Sigma-AldrichRadicicol, Diheterospora chlamydosporia - CAS 12772-57-5 - Calbiochem

Radicicol, Diheterospora chlamydosporia - CAS 12772-57-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

View This Product on Sigma-Aldrich

お勧めの製品

概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
12772-57-5	C₁₈H₁₇ClO₆

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
553400-500UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	500 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable, ATP-site binding, and irreversible antifungal macrocyclic lactone antibiotic that acts as a protein tyrosine kinase inhibitor. Inhibits p60^v-src kinase activity (IC₅₀ = 0.27 nM). Inhibits the expression of COX-2 (IC₅₀ = 27 nM) without affecting COX-1 expression in LPS-stimulated macrophages. Disrupts K-Ras-activated signaling pathways by selectively depleting Raf kinase. Inhibits tyrosine phosphorylation of p53/56^lyn in LPS-stimulated macrophages. Suppresses NIH/3T3 cell transformation by diverse oncogenes such as src, ras, and mos in part by blocking the key signal transduction intermediates such as MAP kinase and GAP-associated p62. Also exhibits anti-angiogenic activity in vivo. Inhibits Wnt-5A expression in dermal papilla cells (IC₅₀ = 190 nM).
Catalogue Number	553400
Brand Family	Calbiochem®

References
References	Shinonaga, H., et al. 2009. Bioorg. Med. Chem. 17, In press. Soga, S., et al. 1998. J. Biol. Chem. 273, 822. Chanmugam, P., et al. 1995. J. Biol. Chem. 270, 5418. Shimada, Y., et al. 1995. J. Antibiot. 48, 824. Zhao, J.F., et al. 1995. Oncogene 11, 161. Oikawa, T., et al. 1993. Eur. J. Pharmacol. 241, 221. Kwon, H.J., et al. 1992. Cancer Res. 52, 6926.

Product Information
CAS number	12772-57-5
Form	White solid
Hill Formula	C₁₈H₁₇ClO₆
Chemical formula	C₁₈H₁₇ClO₆
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	p60^v-src kinase activity
Primary Target IC<sub>50</sub>	0.27 nM
Secondary target	COX-2 (IC₅₀ = 27 nM)
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	RR1105000

Safety Information
R Phrase	R: 20/21/22-36/37/38 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
553400-500UGCN	04055977193602

Documentation

Radicicol, Diheterospora chlamydosporia - CAS 12772-57-5 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Radicicol, Diheterospora chlamydosporia - CAS 12772-57-5 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
553400	ロット番号を入力

参考資料

参考資料の概要
Shinonaga, H., et al. 2009. Bioorg. Med. Chem. 17, In press. Soga, S., et al. 1998. J. Biol. Chem. 273, 822. Chanmugam, P., et al. 1995. J. Biol. Chem. 270, 5418. Shimada, Y., et al. 1995. J. Antibiot. 48, 824. Zhao, J.F., et al. 1995. Oncogene 11, 161. Oikawa, T., et al. 1993. Eur. J. Pharmacol. 241, 221. Kwon, H.J., et al. 1992. Cancer Res. 52, 6926.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-March-2010 RFH
Description	A cell-permeable, ATP-site binding, and irreversible antifungal macrocyclic lactone antibiotic that acts as a protein tyrosine kinase inhibitor. Inhibits p60^v-src kinase activity (IC₅₀ = 0.27 µM). Inhibits the expression of COX-2 (IC₅₀ = 27 nM) without affecting COX-1 expression in LPS-stimulated macrophages. Disrupts k-Ras-activated signaling pathway by selectively depleting Raf kinase. Inhibits tyrosine phosphorylation of p53/56^lyn in LPS-stimulated macrophages. Suppresses NIH 3T3 cell transformation by diverse oncogenes, such as src, ras and mos, at least in part by blocking the key signal transduction intermediates, such as MAP kinase and GAP-associated p62. Also exhibits anti-angiogenic activity in vivo. Inhibits Wnt-5A expression in dermal papilla cells (IC₅₀ = 190 nM).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	12772-57-5
RTECS	RR1105000
Chemical formula	C₁₈H₁₇ClO₆
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (10 mg/ml) or methanol
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Harmful
Merck USA index	14, 6253
References	Shinonaga, H., et al. 2009. Bioorg. Med. Chem. 17, In press. Soga, S., et al. 1998. J. Biol. Chem. 273, 822. Chanmugam, P., et al. 1995. J. Biol. Chem. 270, 5418. Shimada, Y., et al. 1995. J. Antibiot. 48, 824. Zhao, J.F., et al. 1995. Oncogene 11, 161. Oikawa, T., et al. 1993. Eur. J. Pharmacol. 241, 221. Kwon, H.J., et al. 1992. Cancer Res. 52, 6926.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Antibiotics > Antifungal Agents

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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