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553510 RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem

A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis.

RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide, RS-1

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553510
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
312756-74-4C₂₀H₁₆Br₂N₂O₃S

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553510-10MGCN
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      Description
      OverviewA cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis. Although RS-1 enhances hRAD51 filament formation on ssDNA with or without the cofactor NTP, active filaments and recombinase activity are only induced in the presence of ATP or AMP-PNP, but not with ADP or no cofactors. Shown to promote resistance of primary human neonatal dermal fibroblasts to Cisplatin- (Cat. No. 232120) induced death in a dose-dependent manner. RS-1 is inactive toward related DNA strand exchange proteins scRAD5 and scDMC1 of yeast origin or E. coli RedA.This HDR (homology-directed repair) enhancer, is shown to significantly increase both Cas9 & TALEN-mediated knock-in efficiencies.
      Catalogue Number553510
      Brand Family Calbiochem®
      Synonyms3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide, RS-1
      References
      ReferencesSong, J., et al. 2016. Nat. Comm., In Press.
      Jayathilaka, K., et al. 2008. Proc. Natl. Acad. Sci. USA. 105, 15848.
      Product Information
      CAS number312756-74-4
      FormLight beige solid
      Hill FormulaC₂₀H₁₆Br₂N₂O₃S
      Chemical formulaC₂₀H₁₆Br₂N₂O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      553510-10MGCN 04055977193695

      Documentation

      RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      553510

      参考資料

      参考資料の概要
      Song, J., et al. 2016. Nat. Comm., In Press.
      Jayathilaka, K., et al. 2008. Proc. Natl. Acad. Sci. USA. 105, 15848.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-February-2016 MJ
      Synonyms3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide, RS-1
      DescriptionA cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis. Although RS-1 enhances hRAD51 filament formation on ssDNA with or without the cofactor NTP, active filaments and recombinase activity are only induced in the presence of ATP or AMP-PNP, but not with ADP or no cofactors. Shown to promote resistance of primary human neonatal dermal fibroblasts to Cisplatin- (Cat. No. 232120) induced death in a dose-dependent manner. RS-1 is inactive toward related DNA strand exchange proteins scRAD5 and scDMC1 of yeast origin or E. coli RedA.This HDR (homology-directed repair) enhancer, is shown to significantly increase both Cas9 & TALEN-mediated knock-in efficiencies.
      FormLight beige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number312756-74-4
      Chemical formulaC₂₀H₁₆Br₂N₂O₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSong, J., et al. 2016. Nat. Comm., In Press.
      Jayathilaka, K., et al. 2008. Proc. Natl. Acad. Sci. USA. 105, 15848.