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540220 Purmorphamine - CAS 483367-10-8 - Calbiochem

A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM).

Purmorphamine - CAS 483367-10-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist

Primary Target: Activation of the Hedgehog signaling pathway
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540220
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
483367-10-8C₃₁H₃₂N₆O₂

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カタログ番号 在庫状況包装 Qty/Pk 価格 数量
540220-20MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 20 mg
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      540220-5MGCN
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          		 樹脂ｱﾝﾌﾟﾙ 5 mg
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          Description
          OverviewA cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number540220
          Brand Family Calbiochem®
          Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
          References
          ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
          Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.
          Product Information
          CAS number483367-10-8
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₃₁H₃₂N₆O₂
          Chemical formulaC₃₁H₃₂N₆O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetActivation of the Hedgehog signaling pathway
          Primary Target IC<sub>50</sub>EC50 = 1 µM for inducing osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22-68

          Harmful if swallowed.
          Possible risks of irreversible effects.
          S PhraseS: 22-36/37

          Do not breathe dust.
          Wear suitable protective clothing and gloves.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          540220-20MGCN 04055977268737
          540220-5MGCN 07790788051389

          Documentation

          Purmorphamine - CAS 483367-10-8 - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          540220

          参考資料

          参考資料の概要
          Wu, X., et al. 2004. Chem. Biol. 11, 1229.
          Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-November-2014 JSW
          Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
          DescriptionA cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC50 = 1 µM) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number483367-10-8
          Chemical formulaC₃₁H₃₂N₆O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
          Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.