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529659 Pro-survival Compound, DDD00033325 - CAS 1259034-82-6 - Calbiochem

A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background with equal or higher potency than Y-27632.

Pro-survival Compound, DDD00033325 - CAS 1259034-82-6 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: DDD00033325

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529659
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
1259034-82-6C₁₇H₁₉N₅

価格＆在庫状況

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529659-10MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
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      Description
      OverviewA cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50 = 3.9 µM), with equal or higher potency than Y-27632 ((Cat. No. 688000) in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10 µM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (> 83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10 µM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30 µM than Y-27632 without marked adverse effects for up to 120 hours.
      Catalogue Number529659
      Brand Family Calbiochem®
      SynonymsDDD00033325
      References
      ReferencesAndrews, P.D., et al. 2010. Biochem. J. 432, 21.
      Product Information
      CAS number1259034-82-6
      FormYellow syrup
      Hill FormulaC₁₇H₁₉N₅
      Chemical formulaC₁₇H₁₉N₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      529659-10MGCN 04055977269307

      Documentation

      Pro-survival Compound, DDD00033325 - CAS 1259034-82-6 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Pro-survival Compound, DDD00033325 - CAS 1259034-82-6 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      529659

      参考資料

      参考資料の概要
      Andrews, P.D., et al. 2010. Biochem. J. 432, 21.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2012 JSW
      SynonymsDDD00033325
      DescriptionA cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50 = 3.9 µM), with equal or higher potency than Y-27632 ((Cat. No. 688000) in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10 µM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (>83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10 µM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30 µM than Y-27632 without marked adverse effects for up to 120 hours.
      FormYellow syrup
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1259034-82-6
      Chemical formulaC₁₇H₁₉N₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesAndrews, P.D., et al. 2010. Biochem. J. 432, 21.