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506132 Pifithrin-α - CAS 63208-82-2 - Calbiochem

A cell-permeable chemical inhibitor of p53.

Pifithrin-α - CAS 63208-82-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr

Primary Target: PS3
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506132
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
63208-82-2C₁₆H₁₈N₂OS·HBr

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カタログ番号 在庫状況包装 Qty/Pk 価格 数量
506132-10MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 10 mg
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      506132-5MGCN
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          		 樹脂ｱﾝﾌﾟﾙ 5 mg
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          Description
          OverviewA cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.
          Catalogue Number506132
          Brand Family Calbiochem®
          Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
          References
          ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
          Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
          Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
          Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
          Ferber, D. 1999. Science 285, 1651.
          Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
          Komarov, P.G., et al. 1999. Science 285, 1733.
          Product Information
          CAS number63208-82-2
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₆H₁₈N₂OS·HBr
          Chemical formulaC₁₆H₁₈N₂OS·HBr
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPS3
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          506132-10MGCN 04055977199499
          506132-5MGCN 04055977199505

          Documentation

          Pifithrin-α - CAS 63208-82-2 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          Pifithrin-α - CAS 63208-82-2 - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          506132

          参考資料

          参考資料の概要
          Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
          Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
          Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
          Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
          Ferber, D. 1999. Science 285, 1651.
          Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
          Komarov, P.G., et al. 1999. Science 285, 1733.

          カタログ

          タイトル
          Caspases and other Apoptosis Related Tools Brochure
          p53 And Related Products
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
          DescriptionA reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against β-amyloid and glutamate-induced apoptosis.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number63208-82-2
          Chemical formulaC₁₆H₁₈N₂OS·HBr
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
          Toxicity Standard Handling
          ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
          Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
          Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
          Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
          Ferber, D. 1999. Science 285, 1651.
          Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
          Komarov, P.G., et al. 1999. Science 285, 1733.