Millipore Sigma Vibrant Logo

524400 Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.

Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: PMA, TPA, PKC Activator I

Primary Target: Protein Kinase C
View This Product on Sigma-Aldrich
524400
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
16561-29-8C₃₆H₅₆O₈

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
524400-10MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      524400-1MGCN
      在庫状況検索中…
      —
      現在国内在庫なし 現在国内在庫なし
      現在国内在庫有り 
      販売中止
      在庫僅少
      現在国内在庫あり
        Remaining : Will advise
          Remaining : Will advise
          注文対象外
          お問合せください
          Contact Customer Service

          		 ｶﾞﾗｽﾋﾞﾝ 1 mg
          価格を検索中…
          価格が見つかりません
          Minimum Quantity needs to be mulitiple of
          Maximum Quantity is
          弊社照会 詳細を表示　
          値引
          ()
           
          —
          弊社照会
          		 —
          524400-25MGCN
          在庫状況検索中…
          —
          現在国内在庫なし 現在国内在庫なし
          現在国内在庫有り 
          販売中止
          在庫僅少
          現在国内在庫あり
            Remaining : Will advise
              Remaining : Will advise
              注文対象外
              お問合せください
              Contact Customer Service

              		 ｶﾞﾗｽﾋﾞﾝ 25 mg
              価格を検索中…
              価格が見つかりません
              Minimum Quantity needs to be mulitiple of
              Maximum Quantity is
              弊社照会 詳細を表示　
              値引
              ()
               
              —
              弊社照会
              		 —
              524400-5MGCN
              在庫状況検索中…
              —
              現在国内在庫なし 現在国内在庫なし
              現在国内在庫有り 
              販売中止
              在庫僅少
              現在国内在庫あり
                Remaining : Will advise
                  Remaining : Will advise
                  注文対象外
                  お問合せください
                  Contact Customer Service

                  		 ｶﾞﾗｽﾋﾞﾝ 5 mg
                  価格を検索中…
                  価格が見つかりません
                  Minimum Quantity needs to be mulitiple of
                  Maximum Quantity is
                  弊社照会 詳細を表示　
                  値引
                  ()
                   
                  —
                  弊社照会
                  		 —
                  Description
                  OverviewMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mM solution in DMSO (Cat. No. 500582).
                  Catalogue Number524400
                  Brand Family Calbiochem®
                  SynonymsPMA, TPA, PKC Activator I
                  References
                  ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
                  Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
                  Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
                  Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
                  Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
                  Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
                  Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
                  Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
                  Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
                  Perchellet, J. 1985. Carcinogenesis 6, 567.
                  Nishizuka, Y. 1984. Science 255, 1365.
                  Mastro, A. 1982. Lymphokines 6, 263.
                  Product Information
                  CAS number16561-29-8
                  ATP CompetitiveN
                  FormWhite solid
                  Hill FormulaC₃₆H₅₆O₈
                  Chemical formulaC₃₆H₅₆O₈
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ100
                  Applications
                  ApplicationPhorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.
                  Biological Information
                  Primary TargetProtein Kinase C
                  Purity≥98% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSQH4377000
                  Safety Information
                  R PhraseR: 21-38

                  Harmful in contact with skin.
                  Irritating to skin.
                  S PhraseS: 26-27-36-45

                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                  Take off immediately all contaminated clothing.
                  Wear suitable protective clothing.
                  In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Harmful
                  Storage -20°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
                  Packaging Information
                  Packaged under inert gas Packaged under inert gas
                  Transport Information
                  Supplemental Information
                  Specifications
                  Global Trade Item Number
                  カタログ番号 GTIN
                  524400-10MGCN 04055977270952
                  524400-1MGCN 04055977270945
                  524400-25MGCN 04055977270969
                  524400-5MGCN 04055977270976

                  Documentation

                  Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem (M)SDS

                  タイトル

                  英語版製品安全データシート（(M)SDS） 

                  Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem 試験成績書（CoA）

                  タイトルロット番号
                  524400

                  参考資料

                  参考資料の概要
                  Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
                  Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
                  Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
                  Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
                  Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
                  Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
                  Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
                  Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
                  Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
                  Perchellet, J. 1985. Carcinogenesis 6, 567.
                  Nishizuka, Y. 1984. Science 255, 1365.
                  Mastro, A. 1982. Lymphokines 6, 263.

                  カタログ

                  タイトル
                  Caspases and other Apoptosis Related Tools Brochure

                  引用

                  Title
                • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
                • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
                • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
                • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.
                  		•
                  データシート

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision19-October-2010 JSW
                  SynonymsPMA, TPA, PKC Activator I
                  DescriptionExtremely potent mouse skin tumor promoter. Activates protein kinase C (PKC) in vivo and in vitro, even at nanomolar concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Most commonly used phorbol ester.
                  FormWhite solid
                  Intert gas (Yes/No) Packaged under inert gas
                  CAS number16561-29-8
                  RTECSQH4377000
                  Chemical formulaC₃₆H₅₆O₈
                  Structure formulaStructure formula
                  Purity≥98% by HPLC
                  SolubilityDMSO (10 mg/ml). Further dilute with aqueous buffers just prior to use.
                  Storage -20°C
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
                  Toxicity Harmful
                  ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
                  Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
                  Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
                  Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
                  Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
                  Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
                  Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
                  Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
                  Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
                  Perchellet, J. 1985. Carcinogenesis 6, 567.
                  Nishizuka, Y. 1984. Science 255, 1365.
                  Mastro, A. 1982. Lymphokines 6, 263.
                  Citation
                • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
                • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
                • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
                • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.
                  		•