数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

521000 Sigma-AldrichPhenylarsine Oxide - CAS 637-03-6 - Calbiochem

A membrane-permeable protein tyrosine phosphatase inhibitor (IC₅₀ = 18 µM).

Phenylarsine Oxide - CAS 637-03-6 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
カタログ
Data Sheet

同義語: PAO, Oxophenylarsine, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX, PDI Inhibitor II

Primary Target: Protein tyrosine phosphatase

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
637-03-6	C₆H₅AsO

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
521000-250MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	ｱﾙﾐﾆｳﾑｶﾝ	250 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A membrane-permeable protein tyrosine phosphatase inhibitor (IC₅₀ = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56^lck protein tyrosine kinase. Blocks TNF-α-dependent activation of NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts).
Catalogue Number	521000
Brand Family	Calbiochem®
Synonyms	PAO, Oxophenylarsine, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX, PDI Inhibitor II

References
References	Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123. Carey, J.O., et al. 1995. Diabetes 44, 1995. Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067. Oetken, C., et al. 1995. Mol. Immunol. 31, 1295. Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.

Product Information
CAS number	637-03-6
ATP Competitive	N
Form	White solid
Hill Formula	C₆H₅AsO
Chemical formula	C₆H₅AsO
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Protein tyrosine phosphatase
Primary Target IC<sub>50</sub>	18 µM against protein tyrosine phosphatase
Purity	≥96% by titration

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	CH8100000

Safety Information
R Phrase	R: 26/27/28-34-40 Very toxic by inhalation, in contact with skin and if swallowed. Causes burns. Limited evidence of a carcinogenic effect.
S Phrase	S: 26-27-36/37/39-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Take off immediately all contaminated clothing. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
521000-250MGCN	04055977271324

Documentation

Phenylarsine Oxide - CAS 637-03-6 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Phenylarsine Oxide - CAS 637-03-6 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
521000	ロット番号を入力

参考資料

参考資料の概要
Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123. Carey, J.O., et al. 1995. Diabetes 44, 1995. Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067. Oetken, C., et al. 1995. Mol. Immunol. 31, 1295. Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.

カタログ

タイトル
Caspases and other Apoptosis Related Tools Brochure
Protein Phosphatases Technical Bulletin

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	25-September-2008 JSW
Synonyms	PAO, Oxophenylarsine, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX, PDI Inhibitor II
Description	A membrane-permeable phosphotyrosine phosphatase inhibitor (IC₅₀ = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates P56^lck protein tyrosine kinase. Blocks TNFα-dependent activation of the NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases, as well as endogenous chicken caspases that are active in extracts of preapoptotic chicken DU249 cells (S/M extracts). At 100 µM, it also blocks the morphological changes of nuclear apoptosis in vitro and internucleosomal DNA fragmentation in S/M extracts without interfering with PARP or lamin A cleavage. Also known to cause complete and reversible inhibition of NADPH oxidase in human neutrophils.
Form	White solid
CAS number	637-03-6
RTECS	CH8100000
Chemical formula	C₆H₅AsO
Structure formula
Purity	≥96% by titration
Solubility	CHCl₃ (100 mg/ml) or DMSO (50 mg/ml)
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Merck USA index	14, 6949
References	Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123. Carey, J.O., et al. 1995. Diabetes 44, 1995. Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067. Oetken, C., et al. 1995. Mol. Immunol. 31, 1295. Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors

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