Millipore Sigma Vibrant Logo

516483 Pepstatin A, Penetratin - Calbiochem

A Pepstatin A that is ~75% less potent against Cathespins D/E than PepA in cell-free assays.

Pepstatin A, Penetratin - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: PepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈

View This Product on Sigma-Aldrich
516483
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

Empirical Formula
C₁₃₈H₂₂₉N₃₉O₂₈S

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
516483-1MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 1 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.
      Catalogue Number516483
      Brand Family Calbiochem®
      SynonymsPepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈
      References
      ReferencesZaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.
      Product Information
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₃₈H₂₂₉N₃₉O₂₈S
      Chemical formulaC₁₃₈H₂₂₉N₃₉O₂₈S
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Peptide SequencePepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO₂H
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      516483-1MGCN 04055977198843

      Documentation

      Pepstatin A, Penetratin - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Pepstatin A, Penetratin - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      516483

      参考資料

      参考資料の概要
      Zaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2009 RFH
      SynonymsPepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈
      DescriptionA Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃₈H₂₂₉N₃₉O₂₈S
      Peptide SequencePepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO₂H
      Purity≥97% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesZaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.