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580556 Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem

A semi-synthetic form of Paclitaxel having no contamination by natural taxanes. Also has reduced levels of epimerization products as contaminants.

Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
Primary Target: Promotes assembly of microtubules and inhibits tubulin disassembly.
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580556
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
33069-62-4C₄₇H₅₁NO₁₄

価格＆在庫状況

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580556-5MGCN
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      Description
      OverviewA semi-synthetic form of Paclitaxel (Cat. No. 580555) having no contamination by natural taxanes. Also has reduced levels of epimerization products as contaminants.
      Catalogue Number580556
      Brand Family Calbiochem®
      References
      ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
      Product Information
      CAS number33069-62-4
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₄₇H₅₁NO₁₄
      Chemical formulaC₄₇H₅₁NO₁₄
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPromotes assembly of microtubules and inhibits tubulin disassembly.
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDA8340700
      Safety Information
      R PhraseR: 37/38-41-46-60

      Irritating to respiratory system and skin.
      Risk of serious damage to eyes.
      May cause heritable genetic damage.
      May impair fertility.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      580556-5MGCN 04055977265538

      Documentation

      Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      580556

      参考資料

      参考資料の概要
      Derry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-May-2011 JSW
      DescriptionA semi-synthetically derived form of Paclitaxel (TAXOL®, Cat. No. 580555) having no contamination of natural taxanes. Also has less epimerization products as contaminants. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
      FormCrystalline solid
      CAS number33069-62-4
      RTECSDA8340700
      Chemical formulaC₄₇H₅₁NO₁₄
      Purity≥97% by HPLC
      SolubilityDMSO or methanol
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 6982
      ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

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      カタログ番号 説明  
      580555 Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem 価格＆在庫状況を表示

      カテゴリー

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Extracellular Matrix, Adhesion and Cytoskeletal Research Tools