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540216 PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem

The PTP Inhibitor XVIII, also referenced under CAS 1229246-07-4, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Protein Tyrosine Phosphatase Inhibitor XIII, 5-(E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII

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540216
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
1229246-07-4C₁₉H₁₀BrF₆NO₃S

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540216-10MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 10 mg
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      Description
      OverviewA cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 µM, respectively), but not that of LAR even at concentrations as high as 100 µM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound's in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).
      Catalogue Number540216
      Brand Family Calbiochem®
      SynonymsProtein Tyrosine Phosphatase Inhibitor XIII, 5-(E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII
      References
      ReferencesBhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 6161.
      Product Information
      CAS number1229246-07-4
      FormLight yellow powder
      Hill FormulaC₁₉H₁₀BrF₆NO₃S
      Chemical formulaC₁₉H₁₀BrF₆NO₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      540216-10MGCN 04055977268706

      Documentation

      PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      540216

      参考資料

      参考資料の概要
      Bhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 6161.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      SynonymsProtein Tyrosine Phosphatase Inhibitor XIII, 5-(E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII
      DescriptionA cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 µM, respectively), but not that of LAR even at concentrations as high as 100 µM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound's in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).
      FormLight yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1229246-07-4
      Chemical formulaC₁₉H₁₀BrF₆NO₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 6161.