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520222 PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem

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520222
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
82188-90-7C₂₁H₃₃N₆O₃•2HCl

価格&在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
520222-25MGCN
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      樹脂アンプル 25 mg
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      520222-5MGCN
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      現在国内在庫有り 
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          樹脂アンプル 5 mg
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          Description
          OverviewExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H2O (Cat. No. 508773).
          Catalogue Number520222
          Brand Family Calbiochem®
          References
          ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
          Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
          Arni, R.K., et al. 1993. Biochemistry 32, 4727.
          Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
          Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
          Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
          Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
          Product Information
          CAS number82188-90-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₁H₃₃N₆O₃•2HCl
          Chemical formulaC₂₁H₃₃N₆O₃•2HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          ApplicationPPACK, Dihydrochloride, CAS 142036-63-3, is a highly potent, selective & irreversible inhibitor of thrombin. Reacts with thrombin in a 1:1 stoichiometry. Can also inhibit tPA, Factors VIIa & XIa.
          Biological Information
          Primary TargetThrombin
          Primary Target IC<sub>50</sub>Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin
          Purity≥80% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          520222-25MGCN 04055977271294
          520222-5MGCN 07790788051020

          Documentation

          PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート((M)SDS) 

          PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem 試験成績書(CoA)

          タイトルロット番号
          520222

          参考資料

          参考資料の概要
          Rosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
          Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
          Arni, R.K., et al. 1993. Biochemistry 32, 4727.
          Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
          Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
          Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
          Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.

          引用

          Title
        • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.
        • データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2013 JSW
          DescriptionExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator. Factor VIIa, and Factor XIa.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number82188-90-7
          Chemical formulaC₂₁H₃₃N₆O₃•2HCl
          Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
          Purity≥80% by HPLC
          SolubilityH₂O (100 mg/ml)
          Storage Protect from moisture
          Protect from light
          +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
          Toxicity Standard Handling
          Merck USA index14, 7699
          ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
          Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
          Arni, R.K., et al. 1993. Biochemistry 32, 4727.
          Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
          Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
          Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
          Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
          Citation
        • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.