529573 Sigma-AldrichPP2 - CAS 172889-27-9 - Calbiochem
PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively).
More>> PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively). Less<<PP2 - CAS 172889-27-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
同義語: AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
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概要
| Replacement Information |
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主要スペック表
| CAS # | Empirical Formula |
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| 172889-27-9 | C₁₅H₁₆ClN₅ |
価格＆在庫状況
| カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
|---|---|---|---|---|---|---|
| 529573-1MGCN |
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樹脂ｱﾝﾌﾟﾙ | 1 mg |
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| 529573-5MGCN |
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ｶﾞﾗｽﾋﾞﾝ | 5 mg |
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| Description | |
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| Overview | A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 >100 µM). Inhibits the activation of focal adhesion kinase and its phosphorylation at Tyr577. Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM). A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529576) in DMSO also available. |
| Catalogue Number | 529573 |
| Brand Family | Calbiochem® |
| Synonyms | AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine |
| References | |
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| References | Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
| Product Information | |
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| CAS number | 172889-27-9 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₁₅H₁₆ClN₅ |
| Chemical formula | C₁₅H₁₆ClN₅ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Physicochemical Information | |
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| Cell permeable | N |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| カタログ番号 | GTIN |
| 529573-1MGCN | 07790788051198 |
| 529573-5MGCN | 04055977269802 |
Documentation
PP2 - CAS 172889-27-9 - Calbiochem (M)SDS
| タイトル |
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PP2 - CAS 172889-27-9 - Calbiochem 試験成績書（CoA）
| タイトル | ロット番号 |
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| 529573 |
参考資料
| 参考資料の概要 |
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| Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
カタログ
| タイトル |
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| An Introduction to Inhibitors and Their Biological Applications - 1st Edition |
| Bulk Product Guide |
技術情報
| タイトル |
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| Fluorescent Gelatin Degradation Assays for Investigating Invadopodia Formation |
データシート
| タイトル |
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| Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation |
Posters
| タイトル |
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| Human Kinome & InhibitorSelect™ Libraries |
引用
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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