PI3 Kinase (p110α/p65α) Murine

FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
SIZE: 1068 amino acids; 124284 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.

p110α MW = 129kDa, p65α MW = 65.9kDa

Also available in 250μg size --call for pricing and availability and reference catalog number 14-786M when ordering the 250μg size.

Also available in 10 μg size (cat#14-786) and in bulk (cat# 14-786-K).

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

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