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14-792 PI 3-Kinase (p110α(H1047R)/p85α), 10 µg

Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R & untagged, recombinant, human p85α full length.

PI 3-Kinase (p110α(H1047R)/p85α), 10 µg: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
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14-792
10 µg  Also available in 250μg size --call for pricing and availability and reference catalog number 14-792M when ordering the 250μg size.
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      概要

      Replacement Information
      Description
      Catalogue Number14-792
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI 3-Kinase (p110α(H1047R)/p85α), 10 µg
      OverviewComplex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R, and untagged, recombinant, human p85α full length.
      Background InformationThe H1047R substitution is a somatic mutation in p110α that has been associated with tumours of the colon, stomach, breast and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Samuels Y. et al., Science, (2004); 304: 554; Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).
      References
      Product Information
      Presentation50 mM Tris/HCl pH8.0, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
      Quality LevelMQ100
      Applications
      ApplicationComplex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R & untagged, recombinant, human p85α full length.
      Biological Information
      SourceCo-expressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • PIK3CA
      • PI3K
      • PK3CA
      Protein TargetPI3Kα/p85α
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      Molecular Weightp110α(H1047R) MW = 125 kDa, p85α MW = 84 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250μg size --call for pricing and availability and reference catalog number 14-792M when ordering the 250μg size.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      14-792 04053252324574

      Documentation

      PI 3-Kinase (p110α(H1047R)/p85α), 10 µg (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      PI 3-Kinase (p110α(H1047R)/p85α), 10 µg 試験成績書（CoA）

      タイトルロット番号
      PI 3-Kinase (p110#945;(H1047R)/p85#945;) - 1847258-A 1847258-A
      PI 3-Kinase (p110α(H1047R)/p85α) - 2055149-A 2055149-A

      技術情報

      タイトル
      Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?

      データシート

      タイトル
      PI 3-Kinase HTRF Assay

      関連製品＆アプリケーション

      Alternative Packsize

      カタログ番号 説明  
      14-792M PI 3-Kinase (p110α(H1047R)/p85α), 250 µg 価格＆在庫状況を表示

      Accessories

      カタログ番号 説明  
      14-783 PI3 Kinase (p110α(E545K)/p85α), 10 µg 価格＆在庫状況を表示
      14-785 PI3 Kinase (p110α/p85α) murine, 10 µg 価格＆在庫状況を表示
      14-786 PI3 Kinase (p110α/p65α) Murine, 10 µg 価格＆在庫状況を表示
      14-787 PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg 価格＆在庫状況を表示
      14-788 PI3 Kinase (p110β/p85β) Murine, 10 µg 価格＆在庫状況を表示
      14-790 PI3 Kinase (p110α/p65α), 10 µg 価格＆在庫状況を表示
      33-016 PI 3-Kinase HTRF™ Assay; 384 wells 価格＆在庫状況を表示
      33-017 PI 3-Kinase HTRF™ Assay; 1920 wells 価格＆在庫状況を表示
      14-558 PI3 Kinase (p120γ), 20 µg 価格＆在庫状況を表示
      14-602 PI3 Kinase (p110α/p85α) Protein, active, 20 µg 価格＆在庫状況を表示
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      カテゴリー

      Life Science Research > タンパク質と酵素 > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases