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528108 PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem

The PI 3-Kγ Inhibitor II, also referenced under CAS 648449-76-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II

Primary Target: PI 3-Kγ
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528108
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
648449-76-7C₁₁H₅F₂NO₄S

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528108-5MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 5 mg
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      Description
      OverviewA cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
      Catalogue Number528108
      Brand Family Calbiochem®
      Synonyms5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
      References
      ReferencesBilancio, A., et al. 2006. Blood 107, 642.
      Camps, M., et al. 2005. Nat. Med. 11, 936.
      Product Information
      CAS number648449-76-7
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₁₁H₅F₂NO₄S
      Chemical formulaC₁₁H₅F₂NO₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPI 3-Kγ
      Primary Target IC<sub>50</sub>250 nM against PI 3-Kγ
      Primary Target K<sub>i</sub>180 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      528108-5MGCN 04055977270501

      Documentation

      PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      528108

      参考資料

      参考資料の概要
      Bilancio, A., et al. 2006. Blood 107, 642.
      Camps, M., et al. 2005. Nat. Med. 11, 936.

      Posters

      タイトル
      Human Kinome & InhibitorSelect™ Libraries
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-March-2008 RFH
      Synonyms5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
      DescriptionA cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number648449-76-7
      Chemical formulaC₁₁H₅F₂NO₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesBilancio, A., et al. 2006. Blood 107, 642.
      Camps, M., et al. 2005. Nat. Med. 11, 936.