数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

521275 Sigma-AldrichPDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem

The PDK1/Akt/Flt Dual Pathway Inhibitor, also referenced under CAS 331253-86-2, controls the biological activity of PDK1/Akt/Flt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
カタログ
Data Sheet
Posters

同義語: 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one & 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one, Akt Inhibitor XXI, PDK1 Inhibitor I, KP372-1

Primary Target: Both PDK1 and Akt activities

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
331253-86-2	C₁₀H₄N₆O

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
521275-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable compound that selectively induces apoptosis in AML (Acute Myelogenous Leukemia) with little effect on normal CD34⁺ AML progenitor cells. Shown to directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser⁴⁷³ and Thr³⁰⁸. The dual inhibition nature against both PDK1/Akt and Flt3/PIM signaling pathways allows effective killing of AML cells (Average IC₅₀ = 1.05, 1.91, and 0.43 µM for AML with wild-type Flt3, single mutant ITD/D835, and double mutant Flt3-ITD-TDK, respectively) that are otherwise resistant to inhibitors that target only the PDK1/Akt pathway.
Overview	CAS. Nos. 331253-86-2 and 329710-24-9 (two isomers)
Catalogue Number	521275
Brand Family	Calbiochem®
Synonyms	6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one & 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one, Akt Inhibitor XXI, PDK1 Inhibitor I, KP372-1

References
References	Zeng, Z., et al. 2006. Cancer Res. 66, 3737. Koul, D., et al. 2006. Mol. Cancer Ther. 5, 637. Mandal. M., et al. 2006. Oral Oncol. 42, 430. Mandal. M., et al. 2005. Br. J. Cancer 92, 1899.

Product Information
CAS number	331253-86-2
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₁₀H₄N₆O
Chemical formula	C₁₀H₄N₆O
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Both PDK1 and Akt activities
Primary Target IC<sub>50</sub>	1.05, 1.91, and 0.43 µM for AML with wild-type Flt3, single mutant ITD/D835, and double mutant Flt3-ITD-TDK, respectively
Purity	≥98% by HPLC (sum of two isomers)

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
521275-5MGCN	04055977271447

Documentation

PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
521275	ロット番号を入力

参考資料

参考資料の概要
Zeng, Z., et al. 2006. Cancer Res. 66, 3737. Koul, D., et al. 2006. Mol. Cancer Ther. 5, 637. Mandal. M., et al. 2006. Oral Oncol. 42, 430. Mandal. M., et al. 2005. Br. J. Cancer 92, 1899.

カタログ

タイトル
Akt

Posters

タイトル
Human Kinome & InhibitorSelect™ Libraries

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	18-April-2011 RFH
Synonyms	6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one & 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one, Akt Inhibitor XXI, PDK1 Inhibitor I, KP372-1
Description	A cell-permeable compound that selectively induces apoptosis in AML (Acute Myelogenous Leukemia) with little effect on normal CD34⁺ AML progenitor cells. Shown to directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser⁴⁷³ and Thr³⁰⁸. The dual inhibition nature against both PDK1/Akt and Flt3/PIM signaling pathways allows effective killing of AML cells (Average IC₅₀ = 1.05, 1.91, and 0.43 µM for AML with wild-type Flt3, single mutant ITD/D835, and double mutant Flt3-ITD-TDK, respectively) that are otherwise resistant to inhibitors that target only the PDK1/Akt pathway. CAS. No. 331253-86-2 and 329710-24-9.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	331253-86-2
Chemical formula	C₁₀H₄N₆O
Structure formula
Purity	≥98% by HPLC (sum of two isomers)
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Zeng, Z., et al. 2006. Cancer Res. 66, 3737. Koul, D., et al. 2006. Mol. Cancer Ther. 5, 637. Mandal. M., et al. 2006. Oral Oncol. 42, 430. Mandal. M., et al. 2005. Br. J. Cancer 92, 1899.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Akt (Protein Kinase B) Inhibitors

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