Millipore Sigma Vibrant Logo

521231 PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem

The PDGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 249762-74-1, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone, [2-(1H-2-Indolylcarbonyl)-1H-5-indolyl]butanoate, D-65476

Primary Target: PDGFR in swiss 3T3 cells
View This Product on Sigma-Aldrich
521231
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
249762-74-1C₂₁H₁₈N₂O₃

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
521231-1MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 1 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA cell-permeable bis(1H-2-indolyl)-1-methanone compound that acts as a highly selective, ATP-competitive and reversible inhibitor of platelet-derived growth factor (PDGF) receptor tyrosine kinase (IC50 = 1.1 µM in Swiss 3T3 cells for PDGFR). Also potently inhibits Flt3 (Fms-like tyrosine kinase 3) activity (IC50 = 6.2 µM for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells). Sensitizes 32D cells to radiation-induced apoptosis and inhibits proliferation of TEL-Flt3-transfected BA/F3 cells (IC50 < 300 nM). May also serve as a prodrug form of the Platelet Derived Growth Factor Receptor Tyrosine Kinase Inhibitor I (Cat. No. 521230) in cells.
      Catalogue Number521231
      Brand Family Calbiochem®
      Synonyms(5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone, [2-(1H-2-Indolylcarbonyl)-1H-5-indolyl]butanoate, D-65476
      References
      ReferencesMahboobi, S., et al. 2002. J. Med. Chem. 45, 1002.
      Teller, S., et al. 2002. Leukemia 16, 1528.
      Product Information
      CAS number249762-74-1
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₂₁H₁₈N₂O₃
      Chemical formulaC₂₁H₁₈N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDGFR in swiss 3T3 cells
      Primary Target IC<sub>50</sub>1.1 µM inhibiting PDGFR in swiss 3T3 cells; 6.2 µ M for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      521231-1MGCN 04055977271355

      Documentation

      PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      521231

      参考資料

      参考資料の概要
      Mahboobi, S., et al. 2002. J. Med. Chem. 45, 1002.
      Teller, S., et al. 2002. Leukemia 16, 1528.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms(5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone, [2-(1H-2-Indolylcarbonyl)-1H-5-indolyl]butanoate, D-65476
      DescriptionProdrug form of Platelet Derived Growth Factor Receptor Tyrosine Kinase Inhibitor I (Cat. No. 521230) that acts as a highly selective, cell-permeable, ATP-competitive, and reversible inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine kinase (IC50 = 1.1 µM, Swiss 3T3 cells). Also potently inhibits Fms-like tyrosine kinase 3 (Flt3) activity (IC50 = 6.2 µM for PDGFRβ-mFlt3 and 50 nM in EOL-1 cells). Reported to sensitize 32D cells to radiation-induced apoptosis. Also shown to inhibit proliferation of TEL-Flt3-transfected BA/F3 cells (IC50 > 300 nM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number249762-74-1
      Chemical formulaC₂₁H₁₈N₂O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMahboobi, S., et al. 2002. J. Med. Chem. 45, 1002.
      Teller, S., et al. 2002. Leukemia 16, 1528.