数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

528150 Sigma-AldrichPARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem

PARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).

PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

Primary Target: PARP

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
344458-15-7	C₁₇H₁₇N₃O₂ · HCl

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
528150-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
528150-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC₅₀ = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC₅₀ = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H₂O(Cat. No. 528151).
Catalogue Number	528150
Brand Family	Calbiochem®

References
References	Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.

Product Information
CAS number	344458-15-7
ATP Competitive	N
Form	White solid
Hill Formula	C₁₇H₁₇N₃O₂ · HCl
Chemical formula	C₁₇H₁₇N₃O₂ · HCl
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	PARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).

Biological Information
Primary Target	PARP
Primary Target IC<sub>50</sub>	EC50 = 20 nM inhibiting poly(ADP-ribose) polymerase (PARP)
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
528150-1MGCN	04055977196405
528150-5MGCN	04055977196412

Documentation

PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
528150	ロット番号を入力

参考資料

参考資料の概要
Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-January-2008 JSW
Description	A water-soluble phenanthridinone-derivative that acts as a potent anti-inflammatory agent and an inhibitor of poly(ADP-ribose) polymerase (PARP; EC₅₀ = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC₅₀ = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC₅₀ = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	344458-15-7
Chemical formula	C₁₇H₁₇N₃O₂ · HCl
Structure formula
Purity	≥98% by HPLC
Solubility	H₂O (5 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Poly(ADP-ribose) Polymerase (PARP) and Poly(ADP-ribose) Glycohydrolase (PARG) Inhibitors

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