数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

539109 Sigma-AldrichPAR-2 Agonist I - Calbiochem

The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

PAR-2 Agonist I - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: Proteinase Activated Receptor-2 Agonist I, 2f-LIGRL-amide

Primary Target: PAR-2

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

Empirical Formula
C₃₁H₅₃N₉O₇

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
539109-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
539109-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	The native PAR-2-specific agonist, SLIGRL-NH₂, is modified with an N-terminal furoyl group to increase its potency and resistance to metabolic degradation. Shown to activate [Ca²⁺]_i mobilization in PAR-2-expressing cells (EC₅₀ = 253 nM using HCT-15 cells) in vitro and induce PAR-2 mediated salivation (ED₅₀ = 30 nmol/kg, i.v.) in vivo, while exhibiting no effect on PAR-2^-/- mice. Reactive towards human, rat, and murine PAR-2.
Catalogue Number	539109
Brand Family	Calbiochem®
Synonyms	Proteinase Activated Receptor-2 Agonist I, 2f-LIGRL-amide

References
References	Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 108. Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 1098. Ferrell, W.R., et al. 2003. J. Clin. Invest. 111, 35.

Product Information
ATP Competitive	N
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₃₁H₅₃N₉O₇
Chemical formula	C₃₁H₅₃N₉O₇
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	PAR-2
Primary Target IC<sub>50</sub>	EC50 = 253 nM as PAR-2-specific agonist using HCT-15 cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH₂

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
539109-1MGCN	04055977195309
539109-5MGCN	04055977195316

Documentation

PAR-2 Agonist I - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

PAR-2 Agonist I - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
539109	ロット番号を入力

参考資料

参考資料の概要
Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 108. Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 1098. Ferrell, W.R., et al. 2003. J. Clin. Invest. 111, 35.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-September-2008 RFH
Synonyms	Proteinase Activated Receptor-2 Agonist I, 2f-LIGRL-amide
Description	Native proteinase activated receptor-2- (PAR-2) specific agonist, SLIGRL-NH₂, modified with an N-terminal furoyl group to increase its potency and resistance to metabolic degradation. Shown to activate [Ca²⁺]_i mobilization in PAR-2-expressing cells (EC₅₀ = 253 nM in HCT-15 cells) in vitro. Also induces PAR-2-mediated salivation (ED₅₀ = 30 nmol/kg, i.v.) in vivo. Exhibits no effects on PAR-2^-/- mice. Reactive towards human, rat, and mouse PAR-2.
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₃₁H₅₃N₉O₇
Peptide Sequence	2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH₂
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 108. Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 1098. Ferrell, W.R., et al. 2003. J. Clin. Invest. 111, 35.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Other Activators/Agonists

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