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506282 PAD Inhibitor, Cl-amidine - Calbiochem

Cl-amidine is a cell-permeable pan PAD inhibitor (IC₅₀ = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively). Inactivates the calcium bound form of PAD4 in an irreversible manner.

PAD Inhibitor, Cl-amidine - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-Orn amide

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506282
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概要

Replacement Information

主要スペック表

Empirical Formula
C₁₆H₂₀ClF₃N₄O₄

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506282-10MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
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      Description
      OverviewA cell-permeable compound that acts as a pan PAD inhibitor (IC50 = 0.8 µM, 6.2 µM and 5.9 µM for PAD1, PAD3, and PAD4, respectively) in enzymatic assays. It preferentially inactivates the calcium bound form of PAD4 in an irreversible manner, and is shown to complete with BAEE for the active site residue of this enzyme. A small but significant reduction in the efficiency of p300GDB-GRIP1 interaction is observed in transiently transfected CV-1 cells treated with Cl-amidine at concentrations between 25 µM and 200 µM, in vivo . Furthermore, this compound (200 µM) together with HDAC inhibitor SAHA (0.4 µM) has shown additive effects in inducing p21, GADD45, and PUMA expression and inhibiting cancer cell growth in a p53-dependent manner in U2OS cells.
      Catalogue Number506282
      Brand Family Calbiochem®
      SynonymsN-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-Orn amide
      References
      ReferencesKnuckley, B., et al. 2010. Biochemistry 23, 4852.
      Li, P., et al. 2010. Oncogene 21, 3153.
      Luo, Y., et al. 2006. Biochemistry 39, 11727.
      Product Information
      FormWhite solid
      Hill FormulaC₁₆H₂₀ClF₃N₄O₄
      Chemical formulaC₁₆H₂₀ClF₃N₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Purity>95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      506282-10MGCN 04055977272444

      Documentation

      PAD Inhibitor, Cl-amidine - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      PAD Inhibitor, Cl-amidine - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      506282

      参考資料

      参考資料の概要
      Knuckley, B., et al. 2010. Biochemistry 23, 4852.
      Li, P., et al. 2010. Oncogene 21, 3153.
      Luo, Y., et al. 2006. Biochemistry 39, 11727.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-November-2011 RFH
      SynonymsN-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-Orn amide
      DescriptionA cell-permeable compound that acts as a pan PAD inhibitor (IC50 = 0.8 µM, 6.2 µM and 5.9 µM for PAD1, PAD3, and PAD4, respectively) in enzymatic assays. It preferentially inactivates the calcium bound form of PAD4 in an irreversible manner, and is shown to complete with BAEE for the active site residue of this enzyme. A small but significant reduction in the efficiency of p300GDB-GRIP1 interaction is observed in transiently transfected CV-1 cells treated with Cl-amidine at concentrations between 25 µM and 200 µM, in vivo. Furthermore, this compound (200 µM) together with HDAC inhibitor SAHA (0.4 µM) has shown additive effects in inducing p21, GADD45, and PUMA expression and inhibiting cancer cell growth in a p53-dependent manner in U2OS cells.
      FormWhite solid
      Chemical formulaC₁₆H₂₀ClF₃N₄O₄
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesKnuckley, B., et al. 2010. Biochemistry 23, 4852.
      Li, P., et al. 2010. Oncogene 21, 3153.
      Luo, Y., et al. 2006. Biochemistry 39, 11727.