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495320 ODQ - CAS 41443-28-1 - Calbiochem

A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM).

ODQ - CAS 41443-28-1 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

Primary Target: (NO)-sensitive guanylyl cyclase
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495320
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
41443-28-1C₉H₅N₃O₂

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495320-10MGCN
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      Description
      OverviewA cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50 = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
      Catalogue Number495320
      Brand Family Calbiochem®
      Synonyms1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
      References
      ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
      Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527.
      Brunner, F., et al. 1995. FEBS Lett. 376, 262.
      Garthwaite, J., et al. 1995. Mol. Pharmacol. 48, 184.
      Product Information
      CAS number41443-28-1
      ATP CompetitiveN
      FormLight yellow powder
      Hill FormulaC₉H₅N₃O₂
      Chemical formulaC₉H₅N₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target(NO)-sensitive guanylyl cyclase
      Primary Target IC<sub>50</sub>20 nM against nitric oxide (NO)-sensitive guanylyl cyclase
      Purity≥98% by TLC and HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      495320-10MGCN 04055977273045

      Documentation

      ODQ - CAS 41443-28-1 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      ODQ - CAS 41443-28-1 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      495320

      参考資料

      参考資料の概要
      Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
      Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527.
      Brunner, F., et al. 1995. FEBS Lett. 376, 262.
      Garthwaite, J., et al. 1995. Mol. Pharmacol. 48, 184.

      カタログ

      タイトル
      Pathways and Biomarkers of Oxidative Stress
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      Synonyms1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
      DescriptionA potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50 = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ fails to inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
      FormLight yellow powder
      CAS number41443-28-1
      Chemical formulaC₉H₅N₃O₂
      Structure formulaStructure formula
      Purity≥98% by TLC and HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
      Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527.
      Brunner, F., et al. 1995. FEBS Lett. 376, 262.
      Garthwaite, J., et al. 1995. Mol. Pharmacol. 48, 184.