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492041 Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem

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492041
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概要

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CAS #Empirical Formula
75483-04-4C13H₁₂ClNO₃

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492041-25MGCN
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      ガラスビン 25 mg
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      Description
      OverviewA cell-permeable chloro-quinolinone compound that selectively and covalently modifies Kelch-like ECH-associated protein 1 (Keap1)-Cys151 and represses Keap1 function and reduces Nrf2 (Nuclear factor erythroid 2-related factor 2)-Keap1 interaction. Shown to stabilize Nrf2 by inhibiting the Keap1-driven ubiquitination of Nrf2 and thereby activating the Nrf2-ARE (antioxidant response element) pathway (EC50 = 2.7 µM in neuroblastoma IMR-32 cells). Offers protection against H2O2 induced oxidative stress, but unlike tert-butylhydroquinone (Cat. No. 286888). AI-1 does not act as a free radical scavenger. Its anti-oxidant effects are mediated via Nrf2 induced antioxidant response. Does not affect mutant ARE where GC are substituted with AT within the core ARE sequence.
      Catalogue Number492041
      Brand Family Calbiochem®
      SynonymsEthyl-4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
      References
      ReferencesHur, W., et al. 2010. Chem. Biol. 17, 537.
      Product Information
      CAS number75483-04-4
      FormOff-white solid
      Hill FormulaC13H₁₂ClNO₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetKeap1
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      カタログ番号 GTIN
      492041-25MGCN 04055977272772