492041 Sigma-AldrichNrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem
The Nrf2 Activator II, AI-1, also referenced under CAS 75483-04-4, modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The Nrf2 Activator II, AI-1, also referenced under CAS 75483-04-4, modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<同義語: Ethyl-4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
お勧めの製品
概要
主要スペック表
CAS # | Empirical Formula |
---|---|
75483-04-4 | C13H₁₂ClNO₃ |
価格&在庫状況
カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
---|---|---|---|---|---|---|
492041-25MGCN |
|
ガラスビン | 25 mg |
|
— |
Description | |
---|---|
Overview | A cell-permeable chloro-quinolinone compound that selectively and covalently modifies Kelch-like ECH-associated protein 1 (Keap1)-Cys151 and represses Keap1 function and reduces Nrf2 (Nuclear factor erythroid 2-related factor 2)-Keap1 interaction. Shown to stabilize Nrf2 by inhibiting the Keap1-driven ubiquitination of Nrf2 and thereby activating the Nrf2-ARE (antioxidant response element) pathway (EC50 = 2.7 µM in neuroblastoma IMR-32 cells). Offers protection against H2O2 induced oxidative stress, but unlike tert-butylhydroquinone (Cat. No. 286888). AI-1 does not act as a free radical scavenger. Its anti-oxidant effects are mediated via Nrf2 induced antioxidant response. Does not affect mutant ARE where GC are substituted with AT within the core ARE sequence. |
Catalogue Number | 492041 |
Brand Family | Calbiochem® |
Synonyms | Ethyl-4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate |
References | |
---|---|
References | Hur, W., et al. 2010. Chem. Biol. 17, 537. |
Product Information | |
---|---|
CAS number | 75483-04-4 |
Form | Off-white solid |
Hill Formula | C13H₁₂ClNO₃ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
---|---|
Primary Target | Keap1 |
Purity | ≥97% by HPLC |
Physicochemical Information | |
---|---|
Cell permeable | Y |
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
---|---|
カタログ番号 | GTIN |
492041-25MGCN | 04055977272772 |