薬物輸送のためのNon-cell-based Assays
MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.
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参考資料
| 参考資料の概要 |
|---|
| Relationship between structure and high-througput screening permability of diverse drugs with artifical membranes: Application to prediction of Caco-2 cell permeability. Masaaki Fujikawa, Rieko Ano, Kazuya Nakao, Ryo Shimizu and Miki Akamatsu Bioorganic & Medicinal Chemistry 2005 |
| A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis. Balimane, P.V., Pace, E., Chong, S., Zhu, M., Jemal, M., VanPelt, C.K. Journal of Pharmaceutical and Biomedical Analysis 39 (2005): 8-16 2005 |
| Use of ADME screening to conserve resources in drug discovery and development Weiss, A. and Joseph Machamer American Biotechnology Laboratory, January 2004: 16-17 2004 |
| Screening for pharma gold: Researchers are using membrane technologies for high-throughput ADME analysis Lynch, John,Modern Drug Discovery, January 2004: 27-28 Modern Drug Discovery, January 2004: 27-28 2004 |
| Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability Rieko Ano, Yukitaka Kimura, Motohiro Shima, Ryuichi Matsuno, Tamio Ueno and Miki Akamatsu Bioorganic & Medicinal Chemistry 12 (2004) 257-264 2004 |
| Prediction of human intestinal permeability using artificial membrane permeability Kiyohiko Sugano, Yoshiaki Nabuchi, Minoru Machida and Yoshinori Aso International Journal of Pharmaceutics 257 (2003) 245-251 2003 |
FAQ（よくある質問と回答）
| 質問 | 回答 |
|---|---|
| What material is the underdrain support to the Multiscreen plates made of? | The underdrain support is made of polyethylene. |
| What is the well depth and maximum volume capacity of a MultiScreen plate? | The well depth of a 96 well MultiScreen plate is 1.245 cm. The well depth for a 384 well MultiScreen plate is 1.2 cm. The maximum working volume of a 96 well plate is 300 ul. The maximum working volume for a 384 well plate is 100 ul. |