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481984 Nifuroxazide - CAS 965-52-6 - Calbiochem

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity.

Nifuroxazide - CAS 965-52-6 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone

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481984
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
965-52-6C₁₂H₉N₃O₅

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481984-500MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 500 mg
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      Description
      OverviewA cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC50 = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC50 = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.
      Catalogue Number481984
      Brand Family Calbiochem®
      Synonyms5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone
      References
      ReferencesNelson, E.A., et al. 2008. Blood 112, 5095.
      Product Information
      CAS number965-52-6
      FormBright yellow solid
      Hill FormulaC₁₂H₉N₃O₅
      Chemical formulaC₁₂H₉N₃O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      481984-500MGCN 04055977183450

      Documentation

      Nifuroxazide - CAS 965-52-6 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Nifuroxazide - CAS 965-52-6 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      481984

      参考資料

      参考資料の概要
      Nelson, E.A., et al. 2008. Blood 112, 5095.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2009 RFH
      Synonyms5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone
      DescriptionA cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC50 = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC50 = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.
      FormBright yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number965-52-6
      Chemical formulaC₁₂H₉N₃O₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesNelson, E.A., et al. 2008. Blood 112, 5095.